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Recent evidences suggest that obstructive sleep apnea (OSA) can contribute to cardiovascular disease even in the absence of hypertension. However, there are few data regarding the impact of OSA on the sympathetic system in apparently normotensive patients with OSA as well as the impact of treatment with continuous positive airway pressure in different sites of activation (heart, peripheral nerves and circulating catecholamines)
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| CPAP | Experimental | OSA treatment with CPAP |
|
| control | No Intervention | no intervention |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| CPAP | Device | CPAP |
|
| Measure | Description | Time Frame |
|---|---|---|
| improvement in sympathetic activity in muscle sympathetic nerve activity (MSNA) | Improvement in MSNA will be quantified as burst frequency over time (bursts per minute) and as burst frequency corrected for heart rate values (bursts per 100 heartbeats)in the begining and after 3 months. | 3 months |
| Measure | Description | Time Frame |
|---|---|---|
| improvement in sympathetic activity evaluated in different sites of activation | All measurement will be performed at the begining and after 3 months. Blood: blood and 24 hour urine will be collected for norepinephrine quantification. Heart: Early (15 min) and delayed (3 hr) planar images will be taken after injection of (123)I-MIBG. The mean counts of the whole heart and the mediastinum will be obtained to calculate heart-to-mediastinum count ratios from the early images (H/Me) and from the delayed images (H/Md) and the myocardial washout rate (WR). Blood pressure: 24 hour ambulatory blood pressure monitoring and blood pressure during exercise test (treadmill test) |
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Inclusion Criteria:
Exclusion Criteria:
Smoking
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| Name | Affiliation | Role |
|---|---|---|
| Rodrigo Pedrosa, MD, PhD | Heart Institute (InCor) | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Heart Institute | São Paulo | São Paulo | Brazil |
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| 3 months |
| ID | Term |
|---|---|
| D020181 | Sleep Apnea, Obstructive |
| ID | Term |
|---|---|
| D012891 | Sleep Apnea Syndromes |
| D001049 | Apnea |
| D012120 | Respiration Disorders |
| D012140 | Respiratory Tract Diseases |
| D020919 | Sleep Disorders, Intrinsic |
| D020920 | Dyssomnias |
| D012893 | Sleep Wake Disorders |
| D009422 | Nervous System Diseases |
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