Effect of the Addition of Ketamine to Sevoflurane Anesthesia in Electroconvulsive Therapy

Turgut Ozal Medical Center Department of Anesthesiology and Reanimation

The investigators evaluate the effects of a subanesthetic dose of ketamine, administered as an adjunct to sevoflurane, on duration of seizure activity, hemodynamic profile and recovery times during electroconvulsive therapy (ECT) in patients with major depression.

Patients will randomly allocate, to either a sevoflurane-ketamine (Group SK), sevoflurane-saline (Group SS) receiving group. Mean arterial pressure (MAP) and heart rate (HR) will record prior to anesthetic induction (T1); following anesthetic induction (T2); and 0, 1, 3, and 10 min after the seizure has ended (T3, T4, T5, and T6, respectively). Motor and EEG seizure durations will be recorded.

Inclusion Criteria:

• Major depressive patients

Exclusion Criteria:

• Pregnancy
• Have a history of myocardial infarction in the previous six months
• Atrial fibrillation or flutter
• Heart block
• Unregulated hypertension
• Cerebrovascular diseases
• A known drug allergy