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recruitment difficulties
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Open surgery for aneurysmal aortic disease can lead to cardiac, renal, pulmonary or muscular complications, essentially due to the aortic clamping. Ischemic preconditioning can be useful in order to decrease these complications. The investigators would like to use an ischemic preconditioning protocol during open surgery of aortic aneurysm in order to decrease these complications.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Ischemic preconditioning arm | Experimental | Patients will have the ischemic preconditioning protocol 1 hour before the aortic clamping. |
|
| Control patients | Other | Usual surgery assigned to control patients |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Ischemic preconditioning during aortic clamping | Procedure | Ischemic preconditioning during aortic clamping |
|
| Measure | Description | Time Frame |
|---|---|---|
| Myocardial damage measured by troponin level > 0.4 microgr/L (day 1) | Myocardial damage measured by Troponin I level > 0.4 microg/L | Day 1 |
| Measure | Description | Time Frame |
|---|---|---|
| Renal damage | Renal damage measured with Post-operative Creatinin clearance < 50% of Pre-operative creatinin clearance | Day 0, day 1, day 3 or day 5. |
| Muscle weakness | Muscle weakness measured by Creatine phospho Kinase > 200 UI/L |
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Inclusion criteria:
Exclusion criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Anne Lejay, MD | Hôpitaux Universitaires de Strasbourg | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Service de Chirurgie Vasculaire, CH Jean Minjoz | Besançon | 25030 | France | |||
| Service de Chirurgie Vasculaire, CHU le Bocage |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 36645250 | Derived | Liang F, Liu S, Liu G, Liu H, Wang Q, Song B, Yao L. Remote ischaemic preconditioning versus no remote ischaemic preconditioning for vascular and endovascular surgical procedures. Cochrane Database Syst Rev. 2023 Jan 16;1(1):CD008472. doi: 10.1002/14651858.CD008472.pub3. |
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| Procedure/Surgery: usual surgery | Procedure | Procedure/Surgery: usual surgery |
|
| Day 0, day 1, day 3 or day 5 |
| Myocardial damage measured by troponin level > 0.4 microgr/L | Day 0, 3, or 5 |
| Dijon |
| 21079 |
| France |
| Service de Chirurgie vasculaire et transplantation rénale, Nouvel Hôpital Civil, Hôpitaux Universitaires de Strasbourg | Strasbourg | 67091 | France |
| Service de Chirurgie Vasculaire, Hôpitaux Privés de Metz, Site de Mercy | Vantoux | 57070 | France |