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| ID | Type | Description | Link |
|---|---|---|---|
| NCI-2014-01910 | Registry Identifier | CTRP (Clinical Trial Reporting Program) | |
| HS-14-00382 | |||
| 2O-13-1 | Other Identifier | USC Norris Comprehensive Cancer Center | |
| UL1TR000130 | U.S. NIH Grant/Contract | View source | |
| P30CA014089 | U.S. NIH Grant/Contract | View source |
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PI left institution
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| Name | Class |
|---|---|
| National Cancer Institute (NCI) | NIH |
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This pilot research trial studies molecular signatures of the return of cancer after a period of improvement (relapse) in tissue samples from patients with small cell lung cancer who are receiving or planning to receive cisplatin and etoposide. Studying samples of tissue from patients with small cell lung cancer in the laboratory may help doctors learn more about the changes that occur in deoxyribonucleic acid (DNA) and identify biomarkers related to cancer relapse.
PRIMARY OBJECTIVES:
I. To collect and analyze small cell lung cancer (SCLC) tumor DNA and ribonucleic acid (RNA) from 3 human patients before and after relapse to identify the molecular signatures of relapse.
OUTLINE:
Previously collected tissue samples are analyzed via RNA sequencing and DNA methylation at baseline. Patients also undergo collection of tissue samples for analysis at relapse.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Ancillary-Correlative (molecular profile) | Previously collected tissue samples are analyzed via RNA sequencing and DNA methylation at baseline. Patients also undergo collection of tissue samples for analysis at relapse. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| cytology specimen collection procedure | Other | Correlative studies |
|
| Measure | Description | Time Frame |
|---|---|---|
| Change in tumor tissue molecular profiles | Profiles of pre- and post-relapse tumor tissue will be compared. Data will be compared with mouse data and overlaps determined. | Baseline to up to 1 year |
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Inclusion Criteria:
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Subjects seen at USC Norris Comprehensive Cancer Center and at LAC USC Medical Center with histologically confirmed small cell lung cancer will be recruited for this trial.
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| Name | Affiliation | Role |
|---|---|---|
| Barbara Gitlitz | University of Southern California | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Los Angeles County-USC Medical Center | Los Angeles | California | 90033 | United States | ||
| USC Norris Comprehensive Cancer Center |
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Tissue
| laboratory biomarker analysis | Other | Correlative studies |
|
| Los Angeles |
| California |
| 90033 |
| United States |
| ID | Term |
|---|---|
| D055752 | Small Cell Lung Carcinoma |
| ID | Term |
|---|---|
| D002283 | Carcinoma, Bronchogenic |
| D001984 | Bronchial Neoplasms |
| D008175 | Lung Neoplasms |
| D012142 | Respiratory Tract Neoplasms |
| D013899 | Thoracic Neoplasms |
| D009371 | Neoplasms by Site |
| D009369 | Neoplasms |
| D008171 | Lung Diseases |
| D012140 | Respiratory Tract Diseases |
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