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| ID | Type | Description | Link |
|---|---|---|---|
| 2014-A00495-42 | Other Identifier | ID-RCB |
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The identification of the epileptogenic zone (EZ) during pharmacoresistant focal epilepsy presurgical assessment frequently requires intracranial recordings like stereo-electroencephalography (SEEG). Cortical direct electrical stimulation (DES) is commonly used during SEEG for functional mapping or to induce seizure.
However, the recording of seizures is sometimes insufficient to circumscribe the EZ and development of new biomarkers is necessary.
The cortex within the EZ is thought to be hyperexcitable. The "paired pulses" paradigm, using transcranial magnetic stimulation (TMS), allows determining the hemispheric cortical excitability level. The investigators hypothesize that paired pulses DES during SEEG could provide useful information for EZ identification.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| paired pulses cortical electrical stimulation | Experimental |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| paired pulses cortical electrical stimulation | Other |
|
| Measure | Description | Time Frame |
|---|---|---|
| Presence of a significant difference between the evoked responses to paired pulses cortical electrical stimulation of epileptogenic zone cortex and of normal cortex | Low frequency single pulse electrical stimulation induces several cortico-cortical electroencephalographic responses: early-physiological and/or late-pathological. We expect different paired pulses modulation of those responses according the excitability level of the stimulated cortex (in terms of latency, amplitude, surface, frequency power) | between Day 7 and 21 (End of the stereoelectroencephalographic recordings) |
| Measure | Description | Time Frame |
|---|---|---|
| Presence of a difference of responses patterns between anatomic regions and/or lesion type | between Day 7 and 21 (End of the stereoelectroencephalographic recordings ) | |
| Presence of a difference between transcranial magnetic paired pulses stimulations and intracranial paired pulses cortical direct electrical stimulations |
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Inclusion Criteria:
Exclusion Criteria:
Patient with contraindication for MRI scanning
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Sylvain RHEIMS, MD | Contact | 4 17 30 60 64 | +33 | sylvain.rheims@univ-lyon1.fr |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Hôpital neurologique de Lyon | Recruiting | Lyon | 69003 | France |
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| ID | Term |
|---|---|
| D004828 | Epilepsies, Partial |
| ID | Term |
|---|---|
| D004827 | Epilepsy |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
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| Between Day 7 and 21 (End of the stereoelectroencephalographic recordings) |