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Medium Chain Triglycerides (MCT) have been used for many years as a good source of lipid to decrease potential for fat malabsorption. However, the pharmacokinetics of MCT and of their metabolites have not been explored in details.
This is an exploratory study aiming at determining the plasma level of MCT and their metabolites after oral intake of Peptamen.
20 subjects will be given 250mL of peptamen 1.5 twice, with 4 hours of interval, on a single day.
Plasma kinetics of MCTs and their metabolites will be made over 8 hours from baseline
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Peptamen 1.5 | Other | 500 mL of Peptamen 1.5 |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Peptamen 1.5 | Dietary Supplement | Peptamen will be given twice at the dose of 250 mL, with an interval of 4 hours. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Measure of plasma Medium Chain Triglycerides (MCT) | Tmax, Cmax and AUC for MCTs as compared to baseline. | over 8 hours post intake |
| Measure | Description | Time Frame |
|---|---|---|
| Measure of plasma MCT metabolites such as free fatty acids | Tmax, Cmax and AUC for MCT metabolites as compared to baseline | over 8 hours post intake |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Maurice Beaumont, MD,PhD | Metabolic Unit, Clinical Development Unit,Nestec | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Metabolic unit, clinical Development unit, Nestec | Lausanne | 1000 | Switzerland |
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