Criteria of Extubation Failure of Brain Injured Patients. Elaboration of a Prognostic Score.

Criteria of Extubation Failure of Brain Injured Patients. Elaboration of a Prognostic Score.

Identification of criteria associated with extubation failure of brain injured patients. Elaboration of a prognostic score of extubation failure of brain injured patients.

Prospective clinical study in ICU with brain injured ventilated patients eligible to extubation.

Identification of clinical and biological criteria associated with failure of extubation.

Elaboration of a prognostic score of extubation failure of brain injured patients, based on criteria previously identified with multivariate analysis.

Failure of extubation is defined by the need of re-intubation or the need for non-invasive ventilation within 48 hours or more after extubation.

Inclusion Criteria:

• Adult brain injured patients ventilated eligible to discontinuation of mechanical ventilation
• Stable respiratory and hemodynamic conditions
• Ventilated patients for more than 48 hours
• Adequate gaseous exchange (SpO2 ≥ 92% and respiratory rate ≤ 35/min, FiO2 ≤ 40%, positive end-expiratory pressure ≤ 5 cmH2O, pressure support ≤ 8 cmH2O, tidal volume ≥ 7mL/kg
• Therapeutic extubation

Exclusion Criteria:

• • Status epilepticus

  • Cerebrospinal infection
  • Patients under 15 years old
  • Mechanical ventilation of < 48 h
  • Spinal cord injury
  • Withdrawal of life support