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| Name | Class |
|---|---|
| Norwegian Health Association | OTHER |
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High-intensity training (HIT) has repeatedly been documented to have superior positive effects compared to moderate exercise in patients with coronary heart disease and heart failure. Since heart transplant recipients (HTx), have a denervated heart with different respond to exercise, HIT has previously not been introduced among these patients. Rikshospitalet carried out a RCT to investigate this (the TEX study 2009-2012), and found that this form of exercise also was highly effective and safe in long term HTx with clinically significant improvement in VO2peak, muscular exercise capasity, general HRQoL, and even slower progression of CAV (coronary allograft vasculopathy). Based on these findings we ask the following questions in this follow-up study:
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Intervention group | Group that followed high- intensity interval training program in TEX study. | ||
| Control group | Followed up on a regular basis for HTx recipients in Norway. |
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| Measure | Description | Time Frame |
|---|---|---|
| mean VO2peak in the intervention group and control group | We will use the same test protocol as the TEX- study. | 5 years after start of inclusion in RCT (TEX). One measurment. |
| Measure | Description | Time Frame |
|---|---|---|
| How many has progression of cardiac allograft vasculopathy in the intervention group and control group. | Progression of vasculopathy will be studied with IVUS technique, and compared with IVUS pictures from TEX. | 5 years after inclusion in RCT (TEX study). |
| Mean muscle capacity in the intervention group and control group. |
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Inclusion Criteria:
Exclusion Criteria:
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The TEX population.
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| Name | Affiliation | Role |
|---|---|---|
| Lars Gullestad, professor | OUS- kardiologisk avdeling | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| OUS- Rikshospitalet | Oslo | Oslo | 0424 | Norway |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 21765276 | Result | Nytroen K, Myers J, Chan KN, Geiran OR, Gullestad L. Chronotropic responses to exercise in heart transplant recipients: 1-yr follow-up. Am J Phys Med Rehabil. 2011 Jul;90(7):579-88. doi: 10.1097/PHM.0b013e31821f711d. | |
| 22659939 | Result | Nytroen K, Rustad LA, Gude E, Hallen J, Fiane AE, Rolid K, Holm I, Aakhus S, Gullestad L. Muscular exercise capacity and body fat predict VO(2peak) in heart transplant recipients. Eur J Prev Cardiol. 2014 Jan;21(1):21-9. doi: 10.1177/2047487312450540. Epub 2012 Jun 1. |
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Blodsamples from the patients will be studied:
Standard samples: RBC, WBC, plates, CRP, kreatinin, urea, liver tests, thyorid gland tests, lipid profile, fasting- glucose og hba1c, Pro BNP, troponin T, uric acid.
Supplement: Inflammation cytokines/chemokines such as TNF alfa, sTNFR2 og IL-6, IL-10, MCP-1 og IL-8. Growth factors and inhibitors for innervation. Markers for endothelial function; endotelin and von- Willebrand faktor and anti- trombotic factors; fibrinogen, plasminogen activator inhibitor-1.
| 5 years after inclusion in RCT, TEX study. |
| Quality of life | We will use validated questionnaires to estimate quality of life and to evaluate depression. | 5 years after inclusion in TEX- study. |
| Difference in activity level between groups | To estimate activity the study population will fill out a validated questionnaire about physical activity, and they will wear a physical activity monitor at home for one week. | 5 years after inclusion i RCT, TEX study. |
| 23906899 | Result | Nytroen K, Rustad LA, Erikstad I, Aukrust P, Ueland T, Lekva T, Gude E, Wilhelmsen N, Hervold A, Aakhus S, Gullestad L, Arora S. Effect of high-intensity interval training on progression of cardiac allograft vasculopathy. J Heart Lung Transplant. 2013 Nov;32(11):1073-80. doi: 10.1016/j.healun.2013.06.023. Epub 2013 Jul 29. |
| 22900793 | Result | Nytroen K, Rustad LA, Aukrust P, Ueland T, Hallen J, Holm I, Rolid K, Lekva T, Fiane AE, Amlie JP, Aakhus S, Gullestad L. High-intensity interval training improves peak oxygen uptake and muscular exercise capacity in heart transplant recipients. Am J Transplant. 2012 Nov;12(11):3134-42. doi: 10.1111/j.1600-6143.2012.04221.x. Epub 2012 Aug 17. |