Treatment of Negative Symptoms and Schizophrenia

A Double Blind Sham Controlled Trial of tDCS for Treatment of Negative Symptoms in Patients With Schizophrenia

The aim of this study is to evaluate the therapeutic efficacy of a neuromodulation technique, tDCS (transcranial direct current stimulation) used as a complementary treatment on negative symptoms. 60 patients will be randomized into two groups (active tDCS vs sham tDCS) and will be assessed after the intervention, 1 and 3 months after.Secondary outcomes shall include neuropsychological assessment, general symptomatology, extrapyramidal symptoms and social functioning.

• Inclusion Criteria:

  • Schizophrenia with prominent negative symptoms

• Exclusion Criteria:

  • other psychiatric or neurological diseases
  • specific tDCS limitations