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Transcranial direct current stimulation (tDCS) showed beneficial effects on cognition in healthy subjects and depressed patients. In this study, patients with treatment resistant negative syndrome in schizophrenia will be treated with direct current stimulation. fMRI measures will be performed.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| sham | Sham Comparator | patients receive sham tDCS stimulation |
|
| active | Active Comparator | active transcranial direct current stimulation |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| eldith DC-stimulator (neuroconn, Ilmenau, Germany) | Device | daily tDCS treatment over left DLPFC, 20 min, 2 mA |
|
| Measure | Description | Time Frame |
|---|---|---|
| SANS reduction | decrease by 30% | 4 weeks after baseline |
| Measure | Description | Time Frame |
|---|---|---|
| neuropsychological tests | increase in SOPT by 30% increase in TMT by 30% | 4 weeks after baseline |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Ulrich Palm, MD | Ludwig Maximilian University Munich | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Klinik fuer Psychiatrie | Munich | 80336 | Germany |
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| eldith DC-stimulator (Neuroconn, Ilmenau, Germany) | Device | same as sham stimulation |
|
| ID | Term |
|---|---|
| D012559 | Schizophrenia |
| ID | Term |
|---|---|
| D019967 | Schizophrenia Spectrum and Other Psychotic Disorders |
| D001523 | Mental Disorders |
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