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| Name | Class |
|---|---|
| Federal University of Rio Grande do Sul | OTHER |
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In patients with type 2 diabetes, the effects on blood pressure of vitamin D has been shown to be variable. Thus, the goal of this proposal is to evaluate the effect of vitamin D supplementation in patients with type 2 diabetes and hypertension
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| vitamin D3 | Experimental | supplementation of 100.000 IU of vitamin D3 |
|
| Placebo pill | Placebo Comparator | Placebo |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| supplementation of 100.000 IU of vitamin D3 | Dietary Supplement | supplementation of vitamin D ( with 2 pills of Addera D3 (50.000IU each pill)) |
|
| Measure | Description | Time Frame |
|---|---|---|
| Ambulatory Blood pressure monitoring | Blood pressure will be assessed by Ambulatory Blood Pressure Monitoring before and after vitamin D supplementation | up to 24 hours |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| HCPA, Hospital de Clinicas de Porto Alegre | Porto Alegre | Rio Grande do Sul | 90035903 | Brazil |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 33184328 | Derived | de Paula TP, Moreira JSR, Sperb LF, Muller MEP, Steemburgo T, Viana LV. Efficacy of single-dose cholecalciferol in the blood pressure of patients with type 2 diabetes, hypertension and hypovitaminoses D. Sci Rep. 2020 Nov 12;10(1):19611. doi: 10.1038/s41598-020-76646-6. |
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| ID | Term |
|---|---|
| D006973 | Hypertension |
| D003920 | Diabetes Mellitus |
| ID | Term |
|---|---|
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |
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| ID | Term |
|---|---|
| D002762 | Cholecalciferol |
| ID | Term |
|---|---|
| D002782 | Cholestenes |
| D002776 | Cholestanes |
| D013256 | Steroids |
| D000072473 | Fused-Ring Compounds |
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This study was a randomized, double-blind, placebo-controlled clinical trial on 40 outpatients with hypertension and type 2 diabetes were recruited.
Patients were allocated into two equal groups of 20 by computer-generated randomly permutated codes. the subjects were randomly assigned to 1 of 2 groups: Group 1 received a single dose (100.000 IU) of oral supplementation with cholecalciferol (vitamin D3). Group 2 received matching placebo capsules containing microcrystalline cellulose.
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| placebo pill | Dietary Supplement | Placebo |
|
|
| D009750 | Nutritional and Metabolic Diseases |
| D004700 | Endocrine System Diseases |
| D011083 |
| Polycyclic Compounds |
| D013261 | Sterols |
| D014807 | Vitamin D |
| D012632 | Secosteroids |
| D008563 | Membrane Lipids |
| D008055 | Lipids |