Reproducibility and Repeatability of Multifunctional MRI Biomarkers of the Body

Reproducibility and Repeatability of Multifunctional MRI Biomarkers of the Body

Advanced MRI (Magnetic Resonance Imaging) technique called DCE (Dynamic Contrast Enhanced) and DWI MRI can provide valuable information regarding tumor biology and response to treatment through various parameters. Validating stability of these parameters will further establish robustness and reliability of these promising biomarkers.

Inclusion Criteria:

• Diagnosis of metastatic liver cancer proven by pathology
• At least one liver tumor should be > 2cm in long diameter
• Patients with viable tumor proven in the other imaging modalities

Exclusion Criteria:

• Severe claustrophobia
• Presence of MRI-incompatible metallic objects or implanted medical devices in body
• Renal failure, as determined by glomerular filtration rate (GFR) < 30 mL/min/1.73 m2
• Weight greater than that allowable by the MRI table
• Chemotherapy within 28 days prior to enrollment
• Prior external radiation therapy to the liver, prior transarterial chemoembolization