Not provided
Not provided
| ID | Type | Description | Link |
|---|---|---|---|
| P30CA068485 | U.S. NIH Grant/Contract | View source | |
| VU-VICC-BRE-0358 | |||
| VU-VICC-IRB-030472 |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Class |
|---|---|
| National Cancer Institute (NCI) | NIH |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
RATIONALE: Diagnostic procedures, such as dynamic contrast-enhanced magnetic resonance imaging(DCE-MRI), magnetic resonance spectroscopy (MRS), and tissue proteomics, may help doctors find and diagnose breast cancer and plan the best treatment.
PURPOSE: This clinical trial is studying MRI and MRS with or without tissue proteomics analysis to see how well they work in evaluating healthy women and women who are undergoing surgery for breast cancer.
OBJECTIVES:
OUTLINE: Healthy participants undergo dynamic contrast-enhanced (DCE)-MRI and magnetic resonance spectroscopic (MRS) for longitudinal studies of breast imaging and spectroscopy.
Patients with breast cancers undergo DCE-MRI and MRS prior to initiation of treatment (i.e., surgery, chemotherapy, or radiotherapy). After treatment has begun, patients then undergo repeat imaging (not more than 1 per month) for follow-up assessments and longitudinal studies.
Breast tissue samples are collected from patients undergoing surgery. Samples are evaluated by histopathological and proteomic analysis for correlation with DCE-MRI and MRS findings.
The study interventions are discontinued after definitive surgery is performed.
PROJECTED ACCRUAL: A total of 10 healthy participants and 40 patients with breast cancer will be accrued for this study.
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Women with breast cancer | Experimental | Patients undergo DCE-MRI and MRS prior to their breast cancer surgery. |
|
| Healthy volunteers | No Intervention | Women without breast cancer undergo DCE-MRI and MRS. |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| proteomic profiling | Genetic | at the time of each procedure. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Correlation of data obtained by DCE-MRI and magnetic resonance spectroscopy (MRS) with data obtained by conventional X-ray mammography, tissue proteomics, and histopathology in women with breast cancer | Imaging and spectroscopic studies are performed before surgery. After surgery, this data will be compared and contrast with data obtained from conventional mammograms and the patient's tissue. | At time of breast surgery |
| Measure | Description | Time Frame |
|---|---|---|
| Evaluation of the impact of MRS data on treatment planning for radiotherapy and/or surgery in women with breast cancer | Investigators will evaluate the effectiveness of spectroscopic data used to plan for the patient's post-imaging surgery and/or post-surgical radiotherapy. | After the last scan |
Not provided
DISEASE CHARACTERISTICS:
Meets 1 of the following criteria:
Hormone receptor status not specified
PATIENT CHARACTERISTICS:
PRIOR CONCURRENT THERAPY:
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Affiliation | Role |
|---|---|---|
| A. Bapsi Chakravarthy, MD | Vanderbilt-Ingram Cancer Center | Study Chair |
Not provided
Not provided
| ID | Term |
|---|---|
| D001943 | Breast Neoplasms |
| ID | Term |
|---|---|
| D009371 | Neoplasms by Site |
| D009369 | Neoplasms |
| D001941 | Breast Diseases |
| D012871 | Skin Diseases |
Not provided
Not provided
| ID | Term |
|---|---|
| D015412 | Mastectomy, Segmental |
| D008408 | Mastectomy |
| D009682 | Magnetic Resonance Spectroscopy |
| ID | Term |
|---|---|
| D013514 | Surgical Procedures, Operative |
| D013057 | Spectrum Analysis |
| D002623 | Chemistry Techniques, Analytical |
| D008919 | Investigative Techniques |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| lumpectomy or mastectomy | Procedure | removal of breast tumor or removal of the entire breast in which the tumor is located |
|
|
| dynamic contrast-enhanced magnetic resonance imaging | Procedure | Prior to initiation of treatment |
|
|
| histopathologic examination | Procedure | After the breast tumor has been removed, examination of the tumor under a microscope to determine the type and grade of breast cancer |
|
|
| magnetic resonance spectroscopy | Procedure | Prior to initiation of treatment |
|
|
| D017437 |
| Skin and Connective Tissue Diseases |