Group of patients who we will consult the characteristics of the scale designed and will be made the statistical calculations of validity, reliability and reproducibility

The theoretical framework and objectives for the creation of the scale is created. The questionnaire was developed teóricasdel dimensions and items of each dimension are identified. In this testing phase, the pilot is 5 Hematologists physicians experienced in hemophilia (no contact between them) and a sample of the target population (± 12 patients with hemophilia). The structure of this phase include:

• Identify and define the theorical framework of customs and attributes.
• Identification of behaviors that represent the attribute.
• Test design specifications.
• Construction of the items.
• External judgment by judges
• Discussion with the target population
• Analysis of item-objective congruence
• Analysis of the interview with patients and selection of items
• Selection of an initial set of items
• Application of the first version and analysis items
• Selection of items in accordance with standard psychometric

This phase is carried out the questionnaire to a pilot sample (± 50 patients with hemophilia) and the choice of format is made. Similarly, an analysis of differential functioning or bias of the items is performed. The structure of this phase include:

• Implementation of the final scale
• Determination of ground and ceiling effect of the scale
• Analysis of the structure of the scale
• Identifying relevant dimensions
• Calculate the reliability
• Determination of the reproducibility
• Establishing convergent and discriminant validity

This phase is carried out applying the scale to a general sample (patient 100-150). After the statistical and convergence and discriminant analysis (other scales) and the study of responsibility (with drug consumption data) will be made. The structure of this phase include:

• Selecting one or more external criteria
• To establish concurrent validity
• Checking empirical hypotheses
• Determination of responsiveness
• Study interpretability
• Design guidelines for the administration and scoring of scales
• Design cutoff scores