The Effect of Experimental Dentifrices on Remineralization of Caries Lesions In-situ

The Effect of Experimental Dentifrices on Remineralization of Caries Lesions In-situ

This study will evaluate the effect of experimental sodium fluoride-silica dentifrice formulations, with and without zinc, on remineralization of enamel in situ. Following the remineralization phase, the acid resistance of the new mineral formed will be assessed. Fluoride uptake during the remineralization phase will also be measured.

Inclusion Criteria:

• Good general health with no clinically significant and relevant abnormalities of medical history or oral examination
• Participants with maxillary dental arch suitable for the retention of the palatal appliance

Exclusion Criteria:

• Participants taking fluoride supplement
• Pregnant or breast-feeding women