Enamel Remineralization Potential of Dentifrices in Situ

Comparison of Enamel Remineralization Potential of Dentifrices Incorporating Different Fluoride Salts Using an in Situ Caries Model

This study will use an oral in-situ caries model to study remineralization of enamel due to the action of different combinations of fluoride salts delivered from dentifrices.

Inclusion Criteria:

• Good general health with (in the opinion of the investigator) no clinically significant and relevant abnormalities of medical or oral health.
• No current active caries or periodontal disease that may compromise the study or health of the subject.
• All restorations in a good state of repair
• Currently wearing a removable mandibular partial denture with sufficient room in the posterior buccal flange area to accomodate two enamel specimens required dimensions 12 x 7 mm.
• Willing to have their denture modified to accomodate enamel test specimens
• Willing and capable of wearing removable mandibular partial dentures 24 hours per day during the treatment periods.
• Salivary flow rate in the range of normal values (unstimulated whole saliva flow rate greater than or equal to 0.2 mL/ minute; gum base stimulated whole saliva flow rate greater than or equal to 0.8 mL/minute.

Exclusion Criteria:

• Individuals currently taking antibiotics, or who have taken antibiotics within 30 days prior to the first treatment visit.
• Current active caries or periodontal disease that may compromise the study or health of the subject.