The purpose of this study is to investigate reduction of pain, gain of function and improvement of life quality by intraoperative applied platelet- rich- plasma ( PRP ) during knee arthroscopy for degeneration and osteoarthritis OA by conducting a randomized- controlled, double-blinded trial ( RCT ) including 58 patients with a follow up of 12 months and pain, assessed by Visual- Analogue Scale (VAS) after 6 months as primary endpoint.

inclusion Criteria:

• degenerative knee pain
• age: > 18 years
• informed consent
• none to moderate comorbidity
• arthroscopy under general anaesthesia indicated

exclusion Criteria:

• trauma of the knee within the last 6 weeks before surgery
• circumscribed cartilage lesion with possibility of repair microfracture or autologous chondrocyte transplantation - procedures
• contraindications against PRP. application
• malignancies
• severe comorbidities
• age <18 years
• physically or mentally not able to provide informed consent
• severe knee instability
• corticosteroid injections within the last 6 weeks before surgery