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This research through using bispectral index to guide the induced dose and speed of etomidate lipid emulsion for pediatric total venous anesthesia,and to provide a reference for clinical anesthesia physician.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| etomidate group | Experimental | infusion of etomidate at 2 minutes before anesthesia induction |
|
| propofol group | Active Comparator | infusion of propofol at 2 minutes before anesthesia induction |
|
| sevoflurane group | Active Comparator | inhale sevoflurane for anesthesia induction and maintenance |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| etomidate | Drug |
|
| Measure | Description | Time Frame |
|---|---|---|
| the amount of drugs | the amount of etomidate,propofol and sevoflurane used in anesthesia induction | from the beginning of induction to Bispectral Index < 50,up to 5 minutes |
| the drugs used time | the injection time of etomidate and propofol, and the inhale time of sevoflurane during anesthesia induction | from the beginning of induction to Bispectral Index < 50,expected to be within 1 minute |
| numbers of muscular fibrillation | numbers of muscular fibrillation in anesthesia induction | from the beginning of induction to Bispectral Index < 50,up to 5 minutes |
| degree of inflammation reaction | serum levels of interleukin 6 and tumor necrosis factor α will be measured at each time point using ELISA method | baseline,5 minutes after indution,5 minutes before operation end,30 mimutes、24h and 48h after operation |
| adrenal function | serum level of cortisol will be measured at each time point using radioimmunoassay | baseline,5 minutes after indution,5 minutes before operation end,30 mimutes、24h and 48h after operation |
| Measure | Description | Time Frame |
|---|---|---|
| hemodynamic parameters | heart rate,blood pressure,electrocardiogram and pulse oxygen saturation recorded at 4 time points including before anesthesia induction,before endotracheal intubation,after endotracheal intubation and after operation immediately | from the beginning of induction to skin closure, up to 3 hours |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Enqiang Chang | Contact | clinicaltriallh@163.com |
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| ID | Term |
|---|---|
| D005045 | Etomidate |
| D015742 | Propofol |
| D000077149 | Sevoflurane |
| ID | Term |
|---|---|
| D007093 | Imidazoles |
| D001393 | Azoles |
| D006573 | Heterocyclic Compounds, 1-Ring |
| D006571 | Heterocyclic Compounds |
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| propofol | Drug |
|
|
| sevoflurane | Drug |
|
|
| sedation degree |
Bispectral index,train-of-four stimulation and the temperature recorded at 4 time points including before anesthesia induction,before endotracheal intubation,after endotracheal intubation and after operation immediately |
| from the beginning of induction to skin closure, up to 3 hours |
| D010636 |
| Phenols |
| D001555 | Benzene Derivatives |
| D006841 | Hydrocarbons, Aromatic |
| D006844 | Hydrocarbons, Cyclic |
| D006838 | Hydrocarbons |
| D009930 | Organic Chemicals |
| D008738 | Methyl Ethers |
| D004987 | Ethers |
| D006845 | Hydrocarbons, Fluorinated |
| D006846 | Hydrocarbons, Halogenated |