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| Name | Class |
|---|---|
| Foundation Wings For Life | OTHER |
| Balgrist Foundation | UNKNOWN |
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Understanding the onset and progression of spinal cord disorders is an important aim in clinical neurology. An early diagnosis with consequent therapy might prevent the progression of disability. Therefore, we aim to determine structural and dynamic changes in the microstructure of the spinal cord and CSF, and to explore the relationships between the MRI parameters, clinical disability, and electrophysiology.
In some patients that undergo decompressive surgery CSF pressure will be measured invasive perioperative for 24h to find out if functional limitations and structural changes correlate with the spinal pressure and the spinal perfusion when the spinal cord is damaged.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Patients with CSM | |||
| Patients with spinal injury (SCI) | |||
| Healthy controls |
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| Measure | Description | Time Frame |
|---|---|---|
| Morphometric changes and changes in cerebro spinal fluid (CSF) flow and spinal cord movement in patients and control subjects will be correlated to functional deficits and neurophysiological data (regression model analysis). | Each patient will undergo a MRI scan, clinical and electrophysiological examinations at baseline, after 6 months and after 1, 2, 3, 4, and 5 years. Controls will undergo 1 MRI scan and some scan of retest analysis | |
| Assessment of CSF pressure dynamics in the perioperative setting | Perioperative for 24hours |
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Inclusion Criteria:
Exclusion Criteria:
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Subjects with spinal cord disorder and CSM
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Patrick Freund, PhD | Contact | patrick.freund@balgrist.ch |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Zurich, Balgrist University Hospital | Recruiting | Zurich | Canton of Zurich | 8008 | Switzerland |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 38978814 | Derived | Pfender N, Jutzeler CR, Hubli M, Scheuren PS, Pfyffer D, Zipser CM, Rosner J, Friedl S, Sutter R, Spirig JM, Betz M, Schubert M, Seif M, Freund P, Farshad M, Curt A, Hupp M. Potential thresholds of critically increased cardiac-related spinal cord motion in degenerative cervical myelopathy. Front Neurol. 2024 Jun 24;15:1411182. doi: 10.3389/fneur.2024.1411182. eCollection 2024. | |
| 37079108 |
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| ID | Term |
|---|---|
| D013124 | Spinal Injuries |
| ID | Term |
|---|---|
| D019567 | Back Injuries |
| D014947 | Wounds and Injuries |
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| Derived |
| Kheram N, Boraschi A, Pfender N, Spiegelberg A, Kurtcuoglu V, Curt A, Schubert M, Zipser CM. Queckenstedt's test repurposed for the quantitative assessment of the cerebrospinal fluid pulsatility curve. Acta Neurochir (Wien). 2023 Jun;165(6):1533-1543. doi: 10.1007/s00701-023-05583-w. Epub 2023 Apr 20. |
| 32958488 | Derived | Zipser CM, Pfender N, Spirig JM, Betz M, Aguirre J, Hupp M, Farshad M, Curt A, Schubert M. Study protocol for an observational study of cerebrospinal fluid pressure in patients with degenerative cervical myelopathy undergoing surgical deCOMPression of the spinal CORD: the COMP-CORD study. BMJ Open. 2020 Sep 21;10(9):e037332. doi: 10.1136/bmjopen-2020-037332. |