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| ID | Type | Description | Link |
|---|---|---|---|
| FAPESP | Other Grant/Funding Number | 2008/00359-0; 2008/02606-5 |
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| Name | Class |
|---|---|
| Fundação de Amparo à Pesquisa do Estado de São Paulo | OTHER_GOV |
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This study assessed the clinical performance of a resin-modified glass ionomer cement containing different concentrations of chlorhexidine digluconate and doxycycline hyclate.
This study aimed to evaluate the in vivo microbiologic action of the best concentration of chlorhexidine and doxycycline associated with the resin-modified glass ionomer cement applied on remaining dentine after indirect pulp treatment.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Chlorhexidine - CHX | Experimental | Deciduous teeth were filled with GIC containing 1.25% chlorhexidine. |
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| Doxycycline - DOX | Experimental | Deciduous teeth were filled with GIC containing 4.5% doxycycline. |
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| Glass ionomer cement - GIC | Placebo Comparator | Deciduous teeth were filled with GIC without chlorhexidine or doxycycline. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Indirect pulp treatment | Other | Carious dentine was sampled from the mesial portion of the cavity floor and the pulpal wall was entirely covered with one of the randomly selected materials: GIC containing 4.5% DOX; GIC containing 1.25% CHX or GIC as a control group. The antimicrobial concentrations were chosen based in the previous in vitro results obtained in this study. The cavities were then temporarily restored using a conventional GIC. Within 3 months after the initial treatment,the materials were carefully and completely removed, a new dentine sample was collected, and the teeth were then restored with a light-cured composite resin using a bonding system, after a new placement of the initial liner material. |
| Measure | Description | Time Frame |
|---|---|---|
| Indirect Pulp Treatment using GIC associated with 1.25% CHX or 4.5% DOX. | Within 3 months after the initial treatment, the teeth were submitted to clinical and radiographic examination to determine signs and symptoms of pulp vitality. | up to 3 months |
| Measure | Description | Time Frame |
|---|---|---|
| Indirect Pulp Treatment using GIC associated with 1.25% CHX or 4.5% DOX. | Dentine samples were collected at baseline and after 3 months of the treatment for microbiological evaluation (colony-forming unit - CFU). | up to 3 months |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Aline RF Castilho, PhD | Piracicaba Dental School, Unicamp | Principal Investigator |
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| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 23123495 | Result | de Castilho AR, Duque C, Negrini Tde C, Sacono NT, de Paula AB, de Souza Costa CA, Spolidorio DM, Puppin-Rontani RM. In vitro and in vivo investigation of the biological and mechanical behaviour of resin-modified glass-ionomer cement containing chlorhexidine. J Dent. 2013 Feb;41(2):155-63. doi: 10.1016/j.jdent.2012.10.014. Epub 2012 Oct 30. |
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| ID | Term |
|---|---|
| D003731 | Dental Caries |
| ID | Term |
|---|---|
| D017001 | Tooth Demineralization |
| D014076 | Tooth Diseases |
| D009057 | Stomatognathic Diseases |
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