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This is an observational study that will examine the possibility of determining the type of Acute Kidney Injury (AKI) using bedside ultrasound machines.
The investigators hypothesize that different types of AKI (pre-renal, renal, and post-renal) are associated with different inferior vena cava diameters and collapsibility index. The investigators will include subjects ages 18-89 years with AKI (creatinine of 2mg/100ml or higher for less than 24 hours from baseline creatinine ≤1.2 or with unknown baseline creatinine). Standard of care treatment will not be different for patients taking part in this study. Participants will have bedside ultrasounds on days 0, 1, and 3, and baseline and follow-up data will be collected from medical records.
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| Measure | Description | Time Frame |
|---|---|---|
| Maximum and Minimum Diameters of the Inferior Vena Cava in Patients With Acute Kidney Injury | The investigators will measure the maximum and minimum diameters of the inferior vena cava with patients with acute kidney injury. | Day 1 of ICU admission |
| Percent Collapse of the Inferior Vena Cava in Patients With Acute Kidney Injury | The investigators will measure the maximum and minimum diameters of the inferior vena cava with patients with acute kidney injury and calculate the percent change between the maximum and minimum diameters. | Day 1 of ICU admission |
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Inclusion Criteria:
Exclusion Criteria:
1. Only chronic renal disease will exclude a patient from our study regardless of past medical history and medications they are taking. (For the purposes of this study, any patient with creatinine higher than 1.2 mg /100ml for more than 24 hours will be identified as having chronic renal disease.)
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Subjects ages 18-89 years with AKI (creatinine of 1.7mg/100ml or higher for less than 24 hours from baseline creatinine ≤1.2 or with unknown baseline creatinine). Standard of care treatment will not be different for patients taking part in this study. Participants will have bedside ultrasounds on days 0, 1, and 3, and baseline and follow-up data will be collected from medical records.
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| Name | Affiliation | Role |
|---|---|---|
| Kenneth M Nugent, MD | Texas Tech University Health Sciences Center | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Texas Tech Univrsity Health Science Center | Lubbock | Texas | 79430 | United States |
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| ID | Title | Description |
|---|---|---|
| FG000 | Ultrasound of Acute Kidney Injury | This study represents a convenience sample of patients admitted to a medical intensive care unit with laboratory evidence of acute kidney injury. This is a prospective study. There is one study group only. There is no randomization. |
| Title | Milestones | Reasons Not Completed | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Overall Study |
|
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| ID | Title | Description |
|---|---|---|
| BG000 | Ultrasound of Acute Kidney Injury | This study represents a convenience sample of patients admitted to a medical intensive care unit with laboratory evidence of acute kidney injury. This is a prospective study. There is one study group only. There is no randomization. |
| Units | Counts |
|---|---|
| Participants |
|
| Title | Description | Population Description | Parameter Type | Dispersion Type | Unit of Measure | Calculate Percentage | Denominator Units Selected | Denominators | Classes |
|---|---|---|---|---|---|---|---|---|---|
| Age, Continuous | Mean |
| Type | Title | Description | Population Description | Reporting Status | Anticipated Posting Date | Parameter Type | Dispersion Type | Unit of Measure | Calculate Percentage | Time Frame | Units Analyzed | Denominator Units Selected | Arm/Group Information | Denominators | Classes | Analyses | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Primary | Maximum and Minimum Diameters of the Inferior Vena Cava in Patients With Acute Kidney Injury | The investigators will measure the maximum and minimum diameters of the inferior vena cava with patients with acute kidney injury. | Posted | Mean | Standard Deviation | cm | Day 1 of ICU admission |
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Adverse events were collected over the entire study period of approximately 1 year.
This study involved using abdominal ultrasound to measure the inferior vena cava dimensions. This required a short interaction with the patient making this routine measurement with a bedside ultrasound. There were no adverse events
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| ID | Title | Description | Deaths (Affected) | Deaths (At Risk) | Serious Events (Affected) | Serious Events (At Risk) | Other Events (Affected) | Other Events (At Risk) |
|---|---|---|---|---|---|---|---|---|
| EG000 | Ultrasound of Acute Kidney Injury | This study represents a convenience sample of patients admitted to a medical intensive care unit with laboratory evidence of acute kidney injury. This is a prospective study. There is one study group only. There is no randomization. |
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This study is straightforward and involves measurements of the inferior vena cava. The study population was heterogeneous. Study measurements depend on the ability to identify the inferior vena cava with precision and make accurate measurements.
| Title | Organization | Phone | Extension | |
|---|---|---|---|---|
| Dr Kenneth Nugent | Texas Tech university Health Sciences Center, Lubbock, TX | (806) 743-6847 | Kenneth.nugent@ttuhsc.edu |
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| ID | Term |
|---|---|
| D058186 | Acute Kidney Injury |
| ID | Term |
|---|---|
| D051437 | Renal Insufficiency |
| D007674 | Kidney Diseases |
| D014570 | Urologic Diseases |
| D052776 | Female Urogenital Diseases |
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| years |
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| Sex: Female, Male | Count of Participants | Participants |
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| Region of Enrollment | Number | participants |
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| Primary | Percent Collapse of the Inferior Vena Cava in Patients With Acute Kidney Injury | The investigators will measure the maximum and minimum diameters of the inferior vena cava with patients with acute kidney injury and calculate the percent change between the maximum and minimum diameters. | Posted | Mean | Standard Deviation | Percent change | Day 1 of ICU admission |
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| 0 |
| 30 |
| 0 |
| 30 |
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| D005261 |
| Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
| D052801 | Male Urogenital Diseases |