Relations Between Myotonia and Fitness

Relations Between Fitness Status and the Severity of Myotonia in Patients With Congenital Myotonia

Investigators aimed to investigate whether training can increase fitness levels in patients with myotonia, and thereby reduce the symptom of myotonia.

Investigators aimed to investigate whether a 10-week bicycle exercise program can increase fitness levels in patients with myotonia, and thereby reduce the symptom of myotonia in everyday life. The effect on myotonia is assessed by a standardized myotonia scale with six statements concerning self-rated myotonia, and a number of performance tests that objectively describes the degree of myotonia.

The effect of the training program is assessed by an incremental test, measuring maximal oxygen uptake, maximal heart rate and maximal workload. The muscle enzyme creatine kinase (CK) is measured in plasma to follow muscle injury and safety during the training.

Inclusion Criteria:

• Diagnosed with either Myotonia congenita or Paramyotonia congenita.
• Patients who have symptoms of myotonia while they are walking stairs.

Exclusion Criteria:

• Pregnant or breastfeeding women.
• Physical or mental condition, which prevent participating in the study protocol or which could influence the results.
• Participating in other studies, which could influence the results.