Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Investigators aimed to investigate whether training can increase fitness levels in patients with myotonia, and thereby reduce the symptom of myotonia.
Investigators aimed to investigate whether a 10-week bicycle exercise program can increase fitness levels in patients with myotonia, and thereby reduce the symptom of myotonia in everyday life. The effect on myotonia is assessed by a standardized myotonia scale with six statements concerning self-rated myotonia, and a number of performance tests that objectively describes the degree of myotonia.
The effect of the training program is assessed by an incremental test, measuring maximal oxygen uptake, maximal heart rate and maximal workload. The muscle enzyme creatine kinase (CK) is measured in plasma to follow muscle injury and safety during the training.
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Training | Experimental | Participants exercise 3 times a week, 30 minute, on an ergometer bike. |
|
| Control | No Intervention | Participants is tested with the 4 objective myotonia test and measurements of self-assessed myotonia by the Myotonia Behavior Scale is collected. |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Training | Other | 30 minutes of home based pulse watch regulated cycle-ergometer exercise, three times a week at 75% of maximal oxygen consumption. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Changes in myotonia | Changes in myotonia is assessed before and after 10 weeks of exercise training. Myotonia is measured as self-assessment of myotonia using the Myotonia Behavior Scale every day in a week before training start and every day in a week before training finish. Furthermore, myotonia is measured as changes in time climbing a 14 steps stair before and after the 10 weeks training period. | Week 0 and week 10 |
| Measure | Description | Time Frame |
|---|---|---|
| Changes in fitness | An incremental test is performed at baseline and in the end of 10 weeks training. The primary outcome is change between the two tests in maximal oxygen consumption and work load. | baseline and after week 10 |
| Changes in creatine Kinase |
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Affiliation | Role |
|---|---|---|
| Grete Andersen, MD | Neuromuscular research unit Copenhagen | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Neuromuscular Research Unit, Department of Neurology, Rigshospitalet | Copenhagen | 2100 | Denmark |
Not provided
| Label | URL |
|---|---|
| Neuromuscular research unit Copenhagen homepage. | View source |
Not provided
Not provided
| ID | Term |
|---|---|
| D009224 | Myotonia Congenita |
| D009043 | Motor Activity |
| ID | Term |
|---|---|
| D020967 | Myotonic Disorders |
| D009135 | Muscular Diseases |
| D009140 | Musculoskeletal Diseases |
| D020271 | Heredodegenerative Disorders, Nervous System |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Creatine Kinase (CK) is measure in plasma to follow muscle injury during the trial. |
| baseline, week 2, week 4, week 7 and week 10 |
| Changes in other myotonia | Myotonia assessed by eye-open-close test, hand open-close test, and by up-and-go test. The three performance tests describe objectively the degree of myotonia. The outcome measure is changes between before and after training. | baseline and after week 10 |
| D019636 | Neurodegenerative Diseases |
| D009422 | Nervous System Diseases |
| D009468 | Neuromuscular Diseases |
| D030342 | Genetic Diseases, Inborn |
| D009358 | Congenital, Hereditary, and Neonatal Diseases and Abnormalities |
| D001519 | Behavior |