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To examine pancreatic islet function and incretin function during intravenous and oral stimulation >2 years after gastric bypass surgery in patients with normal glucose tolerance. We hypothesize that islet cell and incretin function is enhanced in response to oral, but not intravenous, stimulation - i.e. incretin released from the gut in response to oral stimulation play a key role for the enhanced islet function after gastric bypass surgery.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Patients | Morbidly obese patients with normal glucose tolerance undergoing gastric bypass surgery | ||
| Controls | Age, sex and BMI-matched healthy controls |
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| Measure | Description | Time Frame |
|---|---|---|
| Change in islet cell function from baseline (preoperatively) | Change in insulin and glucagon secretion during oral and intravenous stimulation after gastric bypass | >24 months |
| Measure | Description | Time Frame |
|---|---|---|
| Change in glucose tolerance during oral glucose tolerance test | Fasting, peak and nadir glucose during oral glucose tolerance test | >24 months |
| Arterio-venous glucose difference during oral glucose tolerance test after gastric bypass |
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Inclusion Criteria:
Exclusion Criteria:
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Patients are recruited from the population undergoing gastric bypass surgery at Hvidovre Hospital (Denmark)
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| Name | Affiliation | Role |
|---|---|---|
| Carsten Dirksen, MD, PhD | Hvidovre University Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Hvidovre University Hospital | Hvidovre | Danmark | 2650 | Denmark |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 27138601 | Derived | Dirksen C, Eiken A, Bojsen-Moller KN, Svane MS, Martinussen C, Jorgensen NB, Holst JJ, Madsbad S. No Islet Cell Hyperfunction, but Altered Gut-Islet Regulation and Postprandial Hypoglycemia in Glucose-Tolerant Patients 3 Years After Gastric Bypass Surgery. Obes Surg. 2016 Sep;26(9):2263-2267. doi: 10.1007/s11695-016-2197-x. |
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| ID | Term |
|---|---|
| D009765 | Obesity |
| ID | Term |
|---|---|
| D050177 | Overweight |
| D044343 | Overnutrition |
| D009748 | Nutrition Disorders |
| D009750 | Nutritional and Metabolic Diseases |
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Plasma and serum specimens are retained
Differences in arterial and venous plasma glucose during oral glucose stimulation
| >24 months |
| D001835 |
| Body Weight |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |