The Contribution of Incretin Hormones to the Amelioration of Glucose Metabolism After Roux-en-Y Gastric Bypass

The Contribution of Incretin Hormones to the Amelioration of Glucose Metabolism After Roux-en-Y Gastric Bypass

The study is being undertaken to understand how a gastric bypass can affect a subject's diabetes even prior to their losing significant amounts of weight. The hypothesis of this study is that increased glucagon-like peptide-1 (GLP-1) secretion explains the amelioration in insulin secretion after Roux-en-Y Gastric Bypass (RYGB) surgery.

Inclusion Criteria:

• Subjects with type 2 diabetes mellitus or impaired fasting glucose concentration of > 110 mg/dL
• Subjects registered to receive a Roux-en-Y Gastric Bypass (RYGB).

Exclusion Criteria:

• Subjects taking thiazolidinediones
• Subjects with active systemic illness
• Subjects with active microvascular or macrovascular complications of their diabetes
• For female subject: positive pregnancy test at the time of enrollment in study