Effects of Roux-en-Y Gastric Bypass on Gastro-intestinal Hormone Secretion and Brain Responses Food Pictures

Dynamic Effect of Gastrointestinal Hormones on Cerebral Mechanisms Involved in Brain Perception of Food Pictures After Bariatric Surgery

This is a cross-sectional study enrolling

• 11 weight-stable, formerly obese female patients 1-5 years after Roux-en-Y gastric Bypass (RYGB)
• 11 age- and weight-matched female subjects
• 10 normal weight (Body Mass Index 19-25 kg/m2) subjects The following measurements will be performed in each participants in basal conditions (after an overnight fast) and after ingestion of a standard meal
• electroencephalographic recordings of visually evoked potential after presentation of food- or non-food pictures
• plasma concentration of metabolites (glucose, fatty acids), glucoregulatory hormones (insulin, glucagon), gastro-intestinal hormones (Gastric Inhibitory Polypeptide (GIP), Glucagon-like Peptide-1 (GLP1), ghrelin,Cholecystokinin (CCK), and bile acids Aims of this observational study are
• to evaluate the effects of RYGB on brain perception of food related visual stimulation
• to search for relationships between RYGB effects on brain responses and gastro-intestinal hormone secretion

Inclusion Criteria:

• good apparent health
• gender: female
• age 18-50
• non-smoker

Exclusion Criteria:

• diabetes or antidiabetic medication
• consumption of more than 50g alcohol per week
• vegetarian or any special diet