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This is a cross-sectional study enrolling
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| post Roux-en-Y-gastric bypass | Formerly obese females 1-5 years after gastric bypass |
| |
| matched controls | non-operated females age-and weight-matched to post Roux-en-Y-gastric bypass subjects |
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| healthy young controls | non overweight (BMI between 19 and 25 kg/m2) healthy females |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| standard test meal | Other |
|
| Measure | Description | Time Frame |
|---|---|---|
| Changes of visually-evoked EEG potentials after ingestion of a meal | Recording and analysis of visual evoked potentials (VEPs) while patients categorize photographs of foods and non-food kitchen utensils | basal, 120 min postprandial and 240 postprandial |
| Measure | Description | Time Frame |
|---|---|---|
| changes in plasma triglyceride concentration after ingestion of a meal | Measurement of triglyceride concentrations at 30-60 min intervals in basal conditions (after an overnight fast) and over 6 hours after ingestion of a standard meal) | basal, 90 min postprandial and 180 postprandial |
| Changes in plasma glucoincretins (GLP1 and GIP) concentrations after ingestion of a meal |
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Inclusion Criteria:
Exclusion Criteria:
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Formerly obese patients attending the obesity clinics of Lausanne University Hospital and healthy subjects resident in the Lausanne area
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| Name | Affiliation | Role |
|---|---|---|
| Luc Tappy, MD | University of Lausanne | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| CHUV-clinical research center | Lausanne | Canton of Vaud | CH-1001 | Switzerland |
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| ID | Term |
|---|---|
| D009765 | Obesity |
| ID | Term |
|---|---|
| D050177 | Overweight |
| D044343 | Overnutrition |
| D009748 | Nutrition Disorders |
| D009750 | Nutritional and Metabolic Diseases |
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Measurement of GLP1 and GIP concentrations at 30-60 min intervals in basal conditions (after an overnight fast) and over 6 hours after ingestion of a standard meal) |
| basal, 90 min postprandial and 180 postprandial |
| Changes in plasma cholecystokinin concentrations after ingestion of a meal | Measurement of cholecystokinin concentrations at 30-60 min intervals in basal conditions (after an overnight fast) and over 6 hours after ingestion of a standard meal) | basal, 90 min postprandial and 180 postprandial |
| Changes in plasma bile acids concentrations after ingestion of a meal | Measurement of bile acids concentrations at 30-60 min intervals in basal conditions (after an overnight fast) and over 6 hours after ingestion of a standard meal) | basal, 90 min postprandial and 180 postprandial |
| changes in plasma glucoregulatory status after ingestion of a meal | Measurement of glucose, insulin, glucagon and non-esterified fatty acid concentrations at 30-60 min intervals in basal conditions (after an overnight fast) and over 6 hours after ingestion of a standard meal) | basal, 90 min postprandial and 180 postprandial |
| D001835 |
| Body Weight |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |