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| Name | Class |
|---|---|
| Rijnstate Hospital | OTHER |
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It has been suggested that obese people are more sensitive to sensory and rewarding effects of food, aspects that mediate food preferences and intake. Individuals that underwent Roux-en-Y gastric bypass surgery frequently report changes in food preference. They indicate a decreased preference for highly rewarding energy dense foods. Changes in food preference might be related to alterations in central (brain) mechanisms, related to reward sensing. The smell and sight of food can be considered as anticipatory cues for the rewarding effects of food intake. The aim of this study is to determine the effect of gastric bypass surgery on (alterations in) food preferences. Secondly, this study aims at assessing the effect of gastric bypass surgery on the brain reward response when exposed to sight and smell of food stimuli with different sugar and fat contents.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| RYGB | Food preference assessment in 100 patients at different timepoints, in a subset of 30 participants, also brain reward response to food cues will be assessed. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Roux-en-Y Gastric Bypass | Procedure |
|
| Measure | Description | Time Frame |
|---|---|---|
| Development of food preferences after Roux-en-Y gastric bypass surgery | Food preferences will be assessed 2 weeks before Roux-en-Y Gastric Bypass surgery and 2 months, 1 year and 2 years after surgery. | Participants will be followed for two years after they undergo surgery |
| Change in brain reward response to food cues | Two weeks before and two months after Roux-en-Y Gastric Bypass the brain reward response to the sight and smell of food will be assessed in a subset of 30 participants. | Before and 2 months after surgery |
| Measure | Description | Time Frame |
|---|---|---|
| Plasma levels of endocannabinoids and satiety hormones | Two weeks before and two months after Roux-en-Y gastric bypass surgery, fasted plasma levels of endocannabinoids, ghrelin, leptin, adiponectin and Glucagon-Like Peptide will be assessed in a subset of 30 participants. | Before and 2 months after surgery |
| Measure | Description | Time Frame |
|---|---|---|
| Descriptives | General subject characteristics, e.g. age, gender, restrained eating score and other lifestyle and medical parameters. For the subset of 30 patients that participate in the fMRI measurements: disinhibition scores will be assessed. | Before surgery |
| Appetite ratings |
Inclusion Criteria:
Exclusion Criteria:
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Morbidly obese individuals (age 18-55 years) scheduled for Roux-en-Y gastric bypass surgery at Rijnstate hospital, Arnhem
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| Name | Affiliation | Role |
|---|---|---|
| Suzanne EM de Bruijn, MSc | Wageningen University | Principal Investigator |
| Harriët FA Zoon, MSc | Wageningen University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Rijnstate Hospital | Arnhem | Gelderland | 6800 TA | Netherlands | ||
| Gelderse Vallei Hospital |
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| ID | Term |
|---|---|
| D015390 | Gastric Bypass |
| ID | Term |
|---|---|
| D050110 | Bariatric Surgery |
| D049088 | Bariatrics |
| D000073319 | Obesity Management |
| D013812 | Therapeutics |
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In a subset of 30 participants. |
| During fMRI measurements, i.e., before and two months after surgery |
| Olfactory performance | The Sniffin' Sticks test will be used to assess olfactory performance in the subset of 30 participants that will participate in the fMRI measurements. The sum-score of threshold, discrimination and identification tests will be used to determine if a participant is normosmic. A score of > 30 indicates a participant is normosmic. | At each fMRI measurement, i.e., before and two months after surgery |
| Development of BMI | Before and after surgery |
| Ede |
| Gelderland |
| 6716 RP |
| Netherlands |
| Wageningen University | Wageningen | Gelderland | 6700 EV | Netherlands |
| D005763 |
| Gastroenterostomy |
| D000714 | Anastomosis, Surgical |
| D013514 | Surgical Procedures, Operative |
| D013505 | Digestive System Surgical Procedures |