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The investigators want to investigate if patients with Oculopharyngeal Muscular Dystrophy can improve fitness by home-training on a cycle ergometer 30 minute, 3 times a week for 10 weeks.
Participants will be evaluated on maximal oxygen consumption and maximal workload measured by an incremental test at baseline and at the end of the exercise period.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Excercise | Experimental | 10 weeks of home training on a cycle-ergometer. Exercise 30 minutes every other day or at least three times a week. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Exercise | Behavioral | Ten weeks of home-training on a cycle ergometer 3 times a week for 30 minutes. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Efficacy based on VO2max | Difference in VO2max measured before and after intervention | 10 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| SF-36 Questionaire | Changes in self-rated health from baseline to end of intervention | 10 weeks |
| 6 minute walk test | Changes in walking distance from baseline to end of intervention |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Karen BH Pedersen, Bsc.med. | Neuromuscular Research Unit, Rigshospitalet, Denmark | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Neuromuscular Research Unit | Recruiting | Copenhagen | 2100 | Denmark |
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| Label | URL |
|---|---|
| Website of the Neuromuscular Research Unit, Rigshospitalet, Copenhagen, Denmark | View source |
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| ID | Term |
|---|---|
| D039141 | Muscular Dystrophy, Oculopharyngeal |
| ID | Term |
|---|---|
| D009136 | Muscular Dystrophies |
| D020966 | Muscular Disorders, Atrophic |
| D009135 | Muscular Diseases |
| D009140 | Musculoskeletal Diseases |
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| ID | Term |
|---|---|
| D015444 | Exercise |
| ID | Term |
|---|---|
| D009043 | Motor Activity |
| D009068 | Movement |
| D009142 | Musculoskeletal Physiological Phenomena |
| D055687 | Musculoskeletal and Neural Physiological Phenomena |
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| 10 weeks |
| Intensity in maximal load (Watt) | Changes in maximal load (watt) in the VO2max-test from baseline to end of intervention. | 10 weeks |
| Level of plasma creatine kinase | Marker for exercise-induced muscle damage. Taken week 0,3 and 10. | 10 weeks |
| Level of plasma myoglobin | Marker for excercise-induced muscle damage, taken week 0, 3 and 10. | 10 weeks |
| 6 minute walk test | Changes in walking distance in the test from baseline to end of intervention. | 10 weeks |
| A five-time-repetition-sit-to-stand-test | Changes in time of five repetitions from baseline to end of intervention | 10 weeks |
| A 14-step-stair-test | Changes in time completing the test from baseline to end of intervention | 10 weeks |
| Dynamometry | Changes in external force production from baseline to end of intervention. Dynamometry are measured on hip flexion, dorsal foot flexion, plantar foot flexion, knee flexion, knee extension, and elbow flexion. | 10 weeks |
| D009468 | Neuromuscular Diseases |
| D009422 | Nervous System Diseases |
| D030342 | Genetic Diseases, Inborn |
| D009358 | Congenital, Hereditary, and Neonatal Diseases and Abnormalities |