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| Name | Class |
|---|---|
| Copenhagen University Hospital, Hvidovre | OTHER |
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The purpose of the present project is to investigate the physiological effects of two different types of exercise training in COPD patients. The patients will be examined before, during and after 8 weeks of training to evaluate the effect of different types of skeletal muscle stimulation on health related quality of life, 6 min walking distance, flow mediated dilation, and histological properties of skeletal muscle cells, regarding oxidative capacity, fiber type, purinergic receptor amounts and measures of systemic inflammation. The study will test the hypothesis that:
Resistance training is superior to endurance training in patients with COPD
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Patients with COPD | Experimental | Patients with COPD are to be trained 3 times a week for 8 weeks |
|
| Control patients with COPD | Active Comparator | Control patients with COPD are to be trained 3 times a week for 8 weeks |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Resistance training | Behavioral |
|
|
| Measure | Description | Time Frame |
|---|---|---|
| Skeletal muscle function | Muscle biopsy | At baseline and after 8 weeks of traning |
| Measure | Description | Time Frame |
|---|---|---|
| Flow mediated dilation | Endothelium function | Change from baseline at 8 weeks |
| Body composition | DEXA scan | Change from baseline at 8 weeks |
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Inclusion Criteria:
The medical treatment will be continued unchanged during the study and additional prednisolone and /or antibiotic treatment will be prescribed in case of acute exacerbation.
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Stefan Mortensen, DMSc | Centre of Inflammation and Metabolism, University of Copenhagen, Rigshospitalet | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Centre of Physical Activity Resarch | Copenhagen | Capital Region | 2100 | Denmark | ||
| Centre of Physical Activity Research |
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| ID | Term |
|---|---|
| D029424 | Pulmonary Disease, Chronic Obstructive |
| D009043 | Motor Activity |
| ID | Term |
|---|---|
| D008173 | Lung Diseases, Obstructive |
| D008171 | Lung Diseases |
| D012140 | Respiratory Tract Diseases |
| D002908 | Chronic Disease |
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| ID | Term |
|---|---|
| D055070 | Resistance Training |
| D015444 | Exercise |
| D000076663 | Endurance Training |
| ID | Term |
|---|---|
| D005081 | Exercise Therapy |
| D012046 | Rehabilitation |
| D000359 | Aftercare |
| D003266 | Continuity of Patient Care |
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| Endurance training | Behavioral |
|
| 6 min walking test | Change from baseline at 8 weeks |
| Health Related Quality of Life - COPD assessment test (CAT) | Change from baseline at 8 weeks |
| Copenhagen |
| Capital Region |
| 2100 |
| Denmark |
| D020969 |
| Disease Attributes |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D001519 | Behavior |
| D005791 |
| Patient Care |
| D013812 | Therapeutics |
| D026741 | Physical Therapy Modalities |
| D064797 | Physical Conditioning, Human |
| D009043 | Motor Activity |
| D009068 | Movement |
| D009142 | Musculoskeletal Physiological Phenomena |
| D055687 | Musculoskeletal and Neural Physiological Phenomena |