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Due to technical details recruitment was unreasonably slow
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The purpose of the study is to determine if the administration of a mix of Sufentanil and Morphine in intrathecal is a better analgesia regimen than PCA alone in patient post-VATS.
This study will compare the need for analgesia (Hydromorphone PCA) of two groups of patients post-VATS. The placebo group will only have a PCA for post-operative analgesia, witch is the standard care for patient post-VATS. The experimental group will have a intrathecal injection of a mix of morphine and sufentanil before the induction of anesthesia.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Intrathecal Morphine/Sufentanil and PCA | Active Comparator | Patients will receive an intrathecal injection of Morphine 250 mcg and Sufentanil 10 mcg before the induction of anesthesia. They will have a PCA for analgesia rescue in the post-operative period. |
|
| PCA alone | Placebo Comparator | Patients will NOT receive an intrathecal injection of Morphine 250 mcg and Sufentanil 10 mcg before the induction of anesthesia. They will only have a PCA for analgesia in the post-operative period. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Intrathecal Morphine/Sufentanil | Drug |
| ||
| PCA |
| Measure | Description | Time Frame |
|---|---|---|
| Hydromorphone consommation | The amount of Hydromorphone needed by the patient in the first 24hr after his VATS. | 24hr |
| Measure | Description | Time Frame |
|---|---|---|
| Pain | A VAS will be used. | Every 4h x 24hr |
| Adverse effects of narcotics | Including :
|
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Yanick Sansoucy | Centre de recherche du Centre hospitalier universitaire de Sherbrooke | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Centre hospitalier universitaire de Sherbrooke | Sherbrooke | Quebec | J1H5N4 | Canada |
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| ID | Term |
|---|---|
| D010149 | Pain, Postoperative |
| ID | Term |
|---|---|
| D011183 | Postoperative Complications |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D010146 | Pain |
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| ID | Term |
|---|---|
| D017409 | Sufentanil |
| D010323 | Passive Cutaneous Anaphylaxis |
| D016058 | Analgesia, Patient-Controlled |
| ID | Term |
|---|---|
| D005283 | Fentanyl |
| D010880 | Piperidines |
| D006573 | Heterocyclic Compounds, 1-Ring |
| D006571 | Heterocyclic Compounds |
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| Device |
|
|
| Every 4h x 24hr |
| Adverse reactions associate with rachianesthesia | Including :
| 24hr |
| Adverse reactions of narcotics | Including :
| 24hr |
| D009461 | Neurologic Manifestations |
| D012816 | Signs and Symptoms |
| D012882 |
| Skin Tests |
| D007159 | Immunologic Tests |
| D019411 | Clinical Laboratory Techniques |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
| D008919 | Investigative Techniques |
| D007158 | Immunologic Techniques |
| D000937 | Antigen-Antibody Reactions |
| D055633 | Immune System Phenomena |
| D000698 | Analgesia |
| D000760 | Anesthesia and Analgesia |