Effectiveness Study of Resection of Primary Tumor in Stage IV Colorectal Cancer Patients

Palliative Resection of Asymptomatic Primary Tumor Following Effective Induction Chemotherapy in Colorectal Cancer Patients With Unresectable Distant Metastasis: a Multi-center, Prospective, Randomized Controlled Study

There is still no perfect treatment suggestion for patients with asymptomatic colorectal cancer with unresectable metastatic disease. Whether patients can benefit from palliative resection of primary tumor or not is still waiting for answer. The investigators hypothesis that asymptomatic metastatic colorectal cancer patients who respond to chemotherapy will benefit from primary tumor resection.

Inclusion Criteria:

• 18 to 70 years old
• both genders
• ECOG:0-2 score
• Pathological confirmed colon cancer or rectal cancer with at least 12 cm far away from anal verge
• CT,MRI,or PET-CT confirmed metastasis
• MDT confirmed unresectable metastasis lesion
• No evidence of obstruction, bleeding, perforation
• WBC≥4.0×109/L，Neu ≥2.0×109/L，PLT≥100×109/L
• No contraindication for chemotherapy
• No evidence of other malignant tumor
• Expected survival time > 6 months

Exclusion Criteria:

• mCRC patients who did not respond to first line chemotherapy
• Require surgical intervention during the primary tumor-related symptoms
• Obvious coagulopathy
• Severe heart, liver, kidney damage or other serious uncontrolled medical illness or acute infection, cachexia
• Severe organ damage after chemotherapy, surgery or unable to continue to systemic chemotherapy
• Pregnant or lactating women or women of childbearing age who refuse to accept contraception.
• Nearly three months participated in clinical trials of other persons.
• Mental abnormalities