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| Name | Class |
|---|---|
| The Ministry of Science, Technology and Innovation, Denmark | OTHER_GOV |
| Mental Health Centre Sct. Hans (Denmark) | UNKNOWN |
| University of Copenhagen | OTHER |
The purpose of this study is to determine whether differences in the gene coding for the liver enzyme carboxylesterase 1 (CES1) means differences in the metabolism of methylphenidate, a CES1 dependent drug.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Methylphenidate | Experimental |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Methylphenidate | Drug | 10 mg as a single dose followed by one blood sample 3 hours post-dose |
|
| Measure | Description | Time Frame |
|---|---|---|
| Plasma concentration of methylphenidate and ritalinic acid | We are looking at the ratio of methylphenidate to ritalinic acid (metabolite) 3 hours post-dose as a measure of CES1 activity. | Predose and 3 hours post-dose |
| Measure | Description | Time Frame |
|---|---|---|
| Metabolomic Profile | Three samples for each participant during the trials (as indicated above). Metabolomics will be assessed with focus on lipids (lipid platform) and with use of usual concentration measures (eg nanomolar (nM)) | Predose/pre-meal, predose/post-meal and 3 hours post-dose |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Claus Stage, M.D. | Department of Clinical Pharmacology, Bispebjerg University Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of Clinical Pharmacology, Bispebjerg University Hospital | Copenhagen | 2400 | Denmark |
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| ID | Term |
|---|---|
| D008774 | Methylphenidate |
| ID | Term |
|---|---|
| D010648 | Phenylacetates |
| D000146 | Acids, Carbocyclic |
| D002264 | Carboxylic Acids |
| D009930 | Organic Chemicals |
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| The Leiden Academic Center for Drug Research (LACDR) |
| UNKNOWN |
| Duke University | OTHER |
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| D010880 |
| Piperidines |
| D006573 | Heterocyclic Compounds, 1-Ring |
| D006571 | Heterocyclic Compounds |