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| Name | Class |
|---|---|
| College of Health and Biomedicine, Victoria University | UNKNOWN |
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Coleus forskohlii extract contains the bioactive compound, forskolin. Preliminary studies have shown that forskolin can increase fat metabolism thus reduce fat accumulation in both animals and humans. It has been suggested that forskolin may also suppress appetite thus reduce energy intake and results in weight loss. This study will evaluate the appetite suppressant properties of Coleus forskohlii extract. In addition the effect on central obesity and risk factors of metabolic syndrome will also be investigated.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Coleus forskohlii extract | Experimental | Ingestion of 250 mg capsle (Coleus forskohlii extract) twice a day for 12 weeks |
|
| Placebo | Placebo Comparator | Ingestion of 250 mg capsule (placebo) twice a day for 12 weeks |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Coleus forskohlii extract | Dietary Supplement | Ingestion of 250 mg Coleus forskohlii extract capsule twice a day for 12 weeks |
|
| Measure | Description | Time Frame |
|---|---|---|
| changes in appetite will be assessed using visual analogue scale; blood hormone levels will also be measured using commercial kits. | Baseline and 12 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| reduction in central obesity - waist circumference will be measured on fortnight basis | 12 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| alterations in blood lipids. This will be measured using commercial kits | 12 weeks |
Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Dr. Xiao Su | Contact | +61399192318 | xiao.su@vu.edu.au | |
| Dr HN Shivaprasad | Contact | 918971489704 | shiv@olivelifesciences.com |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| College of Health and Biomedicine Victoria University | Recruiting | St Albans | Victoria | 14428 | Australia |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| Background | obesity | ||
| 24497741 | Background | Shivaprasad HN, Gopalakrishna S, Mariyanna B, Thekkoot M, Reddy R, Tippeswamy BS. Effect of Coleus forskohlii extract on cafeteria diet-induced obesity in rats. Pharmacognosy Res. 2014 Jan;6(1):42-5. doi: 10.4103/0974-8490.122916. |
| Label | URL |
|---|---|
| Coleus forskohlii extract | View source |
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| ID | Term |
|---|---|
| D024821 | Metabolic Syndrome |
| D009765 | Obesity |
| D008659 | Metabolic Diseases |
| ID | Term |
|---|---|
| D007333 | Insulin Resistance |
| D006946 | Hyperinsulinism |
| D044882 | Glucose Metabolism Disorders |
| D009750 | Nutritional and Metabolic Diseases |
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| Placebo | Other | Ingestion of 250 mg placebo capsule twice a day for 12 weeks |
|
| D050177 | Overweight |
| D044343 | Overnutrition |
| D009748 | Nutrition Disorders |
| D001835 | Body Weight |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |