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The purpose of this study is to assess the effects of ramosetron on corrected QT interval in patients undergoing off pump coronary artery bypass surgery.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Ramosetron | Experimental | Intravenous administration of ramosetron 0.3 mg before the induction of general anesthesia |
|
| Control | Placebo Comparator | Intravenous administration of 2ml normal saline before the induction of general anesthesia |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Ramosetron | Drug | 0.3 mg IV as bolus before induction of general anesthesia |
|
| Measure | Description | Time Frame |
|---|---|---|
| corrected QT interval (QTc interval) | at 1,2,3,5,10,15,30,45,60,90,120,240 minutes after ramosetron injection, at the time of operation end, ICU 12hour | up to 240 minutes after induction of general anesthesia |
| Measure | Description | Time Frame |
|---|---|---|
| hypotension or bradycardia during the peri-induction period and the coronary anastomosis period | up to 240 minutes after induction of general anesthesia | |
| incidence of postoperative atrial fibrillation | during the hospital stay (from ICU admission to hospital discharge, average of 1 week) |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Seoul National University Hospital | Seoul | South Korea |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 19261954 | Background | Havrilla PL, Kane-Gill SL, Verrico MM, Seybert AL, Reis SE. Coronary vasospasm and atrial fibrillation associated with ondansetron therapy. Ann Pharmacother. 2009 Mar;43(3):532-6. doi: 10.1345/aph.1L544. Epub 2009 Mar 3. | |
| 22100822 | Background | Sahoo T, SenDasgupta C, Goswami A, Hazra A. Reduction in spinal-induced hypotension with ondansetron in parturients undergoing caesarean section: a double-blind randomised, placebo-controlled study. Int J Obstet Anesth. 2012 Jan;21(1):24-8. doi: 10.1016/j.ijoa.2011.08.002. Epub 2011 Nov 18. |
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| ID | Term |
|---|---|
| D007022 | Hypotension |
| ID | Term |
|---|---|
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
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| ID | Term |
|---|---|
| C071315 | ramosetron |
| D000077330 | Saline Solution |
| ID | Term |
|---|---|
| D000077324 | Crystalloid Solutions |
| D007552 | Isotonic Solutions |
| D012996 | Solutions |
| D004364 | Pharmaceutical Preparations |
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| Normal saline | Drug | 2 ml normal saline as bolus before induction of general anesthesia |
|
| 27488394 | Derived | Kim TK, Cho YJ, Lim CW, Min JJ, Choi EK, Hong DM, Jeon Y. Effect of ramosetron on QTc interval: a randomised controlled trial in patients undergoing off-pump coronary artery bypass surgery. BMC Anesthesiol. 2016 Aug 3;16(1):56. doi: 10.1186/s12871-016-0222-1. |