Effect of Gabapentin on Pain of the Second Cataract Surgery

The Effect of Pretreated Gabapentin on Hyeralgesia Occurring in the Second Operation in Staged Bilateral Cataract Surgery

Gabapentin pretreatment may reduce hyperalgesia occurring at the second surgery in serial, bilateral cataract surgery.

Hyperalgesia occurring at the second operation in bilateral eye surgery is well known, and mechanism of central sensitization might be involved. Gabapentin is known to lower the effect of central sensitization, and its effect on acute postoperative pain has been reported. Therefore, pretreatment of gabapentin after first operation may reduce the pain at second operation.

Inclusion Criteria:

• Patient of ASA(American Cociety of Anesthesiology) class I, II, III between age 20 to 80, scheduled for serial bilateral cataract surgery(1 weel interval)

Exclusion Criteria:

• refuse to participate
• BMI<16 or BMI >30
• severe cardiovascular, pulmonary, renal disease
• alcohol or drug abuse
• currently taking CNS(central nervous system) inhibitory drugs
• taking antiacids
• depressive disorder pregnancy