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Our study involves the evaluation of a high potency chemical peel in its efficacy and safety profile for the treatment of acne scars. This chemical peel regime is a high potency peel of 70% glycolic acid combined with vitamin C that is purported to provide a good balance between yielding results and patient safety. We aim to evaluate its efficacy and safety profile of a single application. The study design is based on a single group that compares pre- vs post-intervention. 10 patients with atrophic acne scars of skin type I-IV will be recruited. Potential benefits include improvement of post acne scars with a short downtime and risks include post peel hyper pigmentation and scarring. We believe that this treatment will be highly beneficial to patients with post acne scarring.
This chemical peel regime has good efficacy and safety profile for the treatment of acne scars.
Primary endpoints:
Secondary endpoints:
Postacne hyperpigmentation index (PAHPI)
-Each of these 3 variables --size, intensity, and number of lesions is weighted and the summation of the weighted variables gives the total PAHPI score, ranging 6 to 22.
Safety Assessment (This is an ordinal scale) i. Score of redness ii. Score of swelling iii. Score of oozing/crusting iv. Post peel hyperpigmentation v. Post peel scarring vi. Assessment based on patient and doctor global assessment (global assessment from 1 - 10)
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Single Arm | Other | Single arm study - pre and post peel assessment |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| 70% glycolic acid | Drug |
|
| Measure | Description | Time Frame |
|---|---|---|
| Efficacy Assessment |
Secondary endpoints 1) Postacne hyperpigmentation index (PAHPI) | 3 months |
| Safety Assessment | ) Safety Assessment (This is also an ordinal scale) i. Score of redness ii. Score of swelling iii. Score of oozing/crusting iv. Post peel hyperpigmentation v. Post peel scarring | 3 months |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Sam SY Yang, Dr | Contact | 85333992 | samsyyang@gmail.com |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| National University Hospital | Singapore | Singapore | 119074 | Singapore |
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| ID | Term |
|---|---|
| C031149 | glycolic acid |
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