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Pregabalin is claimed to have superior analgesic effect at lower doses and better pharmacological profile as compared to gabapentin esp. in perioperative pain control after major surgeries like intervertebral disc surgery.
The investigators found that pregabalin is equivalent to gabapentin for relief of post-operative pain at a lower dose in patients undergoing intervertebral disc surgery.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| gabapentin | Active Comparator |
| |
| Pregabalin | Active Comparator |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Pregabalin | Drug | Pregablin 75 mg per oral two times a day |
| |
| Measure | Description | Time Frame |
|---|---|---|
| Pain | Pain measurement using Visual Analogue Score at 24 hours and 7th day of surgery | 7 days |
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Inclusion Criteria:
Exclusion Criteria:
9) patients with known allergy to GABA analogues.
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| Name | Affiliation | Role |
|---|---|---|
| Mohsin Qadeer, FCPS | The Aga Khan University Hospital, Karachi, Pakistan | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| The Aga Khan University Hospital | Karachi | Sindh | 75300 | Pakistan |
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| ID | Term |
|---|---|
| D007405 | Intervertebral Disc Displacement |
| D010146 | Pain |
| ID | Term |
|---|---|
| D013122 | Spinal Diseases |
| D001847 | Bone Diseases |
| D009140 | Musculoskeletal Diseases |
| D006547 | Hernia |
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| ID | Term |
|---|---|
| D000069583 | Pregabalin |
| D000077206 | Gabapentin |
| ID | Term |
|---|---|
| D005680 | gamma-Aminobutyric Acid |
| D000613 | Aminobutyrates |
| D002087 | Butyrates |
| D000144 | Acids, Acyclic |
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| Gabapentin |
| Drug |
Gabapentin 200 mg twice daily per oral |
|
| D020763 |
| Pathological Conditions, Anatomical |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D009461 | Neurologic Manifestations |
| D012816 | Signs and Symptoms |
| D002264 |
| Carboxylic Acids |
| D009930 | Organic Chemicals |
| D000596 | Amino Acids |
| D000602 | Amino Acids, Peptides, and Proteins |
| D000588 | Amines |
| D003509 | Cyclohexanecarboxylic Acids |
| D000146 | Acids, Carbocyclic |
| D003510 | Cyclohexanes |
| D003516 | Cycloparaffins |
| D006840 | Hydrocarbons, Alicyclic |
| D006844 | Hydrocarbons, Cyclic |
| D006838 | Hydrocarbons |