Characterization of Changes in Ventricular Mechanics in Response to Lexiscan Stress Using Tagged Cine Cardiac Magnetic Resonance Imaging

Characterization of Changes in Ventricular Mechanics in Response to Lexiscan Stress Using Tagged Cine Cardiac Magnetic Resonance Imaging

The purpose of this study is to measure the changes in cardiac function during a Lexiscan pharmacologic stress test using cardiac magnetic resonance imaging test.

Inclusion Criteria:

• Myocardial rest/regadenoson stress perfusion PET study within 60 days
• Normal rest LVEF (greater than or equal to 50%)
• No change in symptoms or treatment between the PET and the MRI study
• Willing to consent to the study
• Male or female who is either post-menopausal, surgically sterile, or if has a childbearing potential, a negative pregnancy test within 2 days prior to the MRI study.

Exclusion Criteria:

• Renal dysfunction (estimated glomerular filtration rate < 60 mL/min/1.73m2) within 6 months
• Metallic implants, pacemaker, blood vessel clip (contra-indicated for MRI)
• Patient size exceeds MRI bore/table limits: (Max body diameter > 60 cm, weight > 136 kg)
• History of gadolinium contrast allergy or intolerance
• Second or third degree AV block
• Sinus node dysfunction
• Acute myocardial infarction (past 3 months)
• Actively wheezing or with acute asthma or bronchospastic attacks requiring changes in therapy within the past 30 days
• Patients that have experienced a previous hypersensitivity reaction thought to be related to regadenoson