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| Name | Class |
|---|---|
| University of Michigan | OTHER |
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Community Awareness, Resources and Education (CARE) Project - Project 3 will determine if Appalachian women have unique risk factors for an abnormal Pap smear that might contribute to the increased risk of cervical abnormalities, specifically cancer, in their communities.
The aim of CARE: Project 3 is to determine the social, behavioral, and biological variables that might contribute to increased risks of an abnormal Pap smear in Appalachian women in Ohio. To accomplish these aims, a case-control study was proposed. Women age 18 and older with an intact cervix, not pregnant, and no current or past history of invasive cervical cancer are recruited at the time of their scheduled Pap smear from clinics/physician practices in Appalachian region of Ohio. Women receiving Pap tests at participating medical clinics/physician practices are recruited for a case control epidemiologic study assessing HPV prevalence and its impact on cervical intraepithelial neoplasia (CIN). Cervical mucus will be collected for Human Papillomavirus (HPV) assays and stored for potential other assays related to HPV. Serum will be drawn for HPV serology and stored for future analysis. Controls are defined as women with a normal Pap smear. Cases are defined as women with abnormal Pap smear (from atypical squamous cells of uncertain significance (ASCUS) to cancer.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Normal Pap smear | Women with normal pap test. | ||
| Abnormal Pap smear | Women with abnormal pap test. |
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| Measure | Description | Time Frame |
|---|---|---|
| Social/environmental variables of access to screening were analyzed to see if they contribute to increased risk of developing abnormalities among Appalachian women. | On the day of study enrollment, survey data and specimens were obtained from the participants. | Participant completed all activites on the 1 day of the clinic visit. |
| Measure | Description | Time Frame |
|---|---|---|
| Behavioral variables of age of onset of sexual intercourse, number of partners, male partner factors, multiparity, oral contraceptive use, and smoking were analyzed to see if they contribute to the increased risk of developing abnormalities. | On the day of study enrollment, survey data and specimens were obtained from the participants. | Participant completed all activites on the 1 day of the clinic visit. |
| Measure | Description | Time Frame |
|---|---|---|
| Factors that impede follow-up and treatment of abnormal or suspicious Pap smear findings were identified. | On the day of study enrollment, survey data and specimens were obtained from the participants. | Participant completed all activites on the 1 day of the clinic visit. |
| New molecular markers related to cervical cancer were explored. |
Inclusion Criteria:
Exclusion Criteria:
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Woman 18 years or older that are nonpregnant with intact cervix and no cervical cancer who present for a Pap smear. Must be residents of an Appalacian Ohio county.
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| Name | Affiliation | Role |
|---|---|---|
| Electra D. Paskett, PhD | The Ohio State University Center for Population Health and Health Disparities | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Michigan | Ann Arbor | Michigan | 48109 | United States | ||
| The Ohio State University |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 22664184 | Background | Patel DA, Rozek LS, Colacino JA, Van Zomeren-Dohm A, Ruffin MT, Unger ER, Dolinoy DC, Swan DC, Onyekwuluje J, DeGraffinreid CR, Paskett ED. Patterns of cellular and HPV 16 methylation as biomarkers for cervical neoplasia. J Virol Methods. 2012 Sep;184(1-2):84-92. doi: 10.1016/j.jviromet.2012.05.022. Epub 2012 Jun 1. | |
| 22749839 |
| Label | URL |
|---|---|
| Jamesline | View source |
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Cervical mucus will be collected for Human Papillomavirus (HPV) assays and stored for potential other assays related to HPV. Serum will be drawn for HPV serology and stored for future analysis.
| Biological variables of HPV status, HPV type, HPV variants, HPV viral load, and serology to HPV were analyzed to see if they contribute to the increased risk of developing cervical abnormalities among Appalachian women. | On the day of study enrollment, survey data and specimens were obtained from the participants. | Participant completed all activites on the 1 day of the clinic visit. |
| Combinations of social, behavioral, and biological determinants were analyzed to see which contribute to the increased risk of developing cervical abnormalities among Appalachian women. | On the day of study enrollment, survey data and specimens were obtained from the participants. | Participant completed all activites on the 1 day of the clinic visit. |
On the day of study enrollment, survey data and specimens were obtained from the participants. |
| Participant completed all activites on the 1 day of the clinic visit. |
| Columbus |
| Ohio |
| 43201 |
| United States |
| Ruffin MT 4th, Hade EM, Gorsline MR, DeGraffinreid CR, Katz ML, Kobrin SC, Paskett ED. Human papillomavirus vaccine knowledge and hypothetical acceptance among women in Appalachia Ohio. Vaccine. 2012 Aug 3;30(36):5349-57. doi: 10.1016/j.vaccine.2012.06.034. Epub 2012 Jun 27. |
| 24023700 | Result | Reiter PL, Katz ML, Ruffin MT, Hade EM, DeGraffenreid CR, Patel DA, Paskett ED, Unger ER. HPV prevalence among women from Appalachia: results from the CARE project. PLoS One. 2013 Aug 30;8(8):e74276. doi: 10.1371/journal.pone.0074276. eCollection 2013. |