Chemotherapy Combined With Radiotherapy vs Chemotherapy Alone for Distant Metastatic Nasopharyngeal Carcinoma

Multicentre Randomization Clinic Trial of Systemic Chemotherapy Combined With Loco-regional Radiotherapy vs. Chemotherapy Alone for Initially Untreated Distant Metastatic Nasopharyngeal Carcinoma With Chemosensitivity

This is a randomized parallel control trial to evaluate whether radical loco-regional Radiotherapy can prolong survival time of initial untreated metastatic nasopharyngeal carcinoma.

Inclusion Criteria:

• The patients with initial untreated metastatic nasopharyngeal carcinoma
• Histologic diagnosis of nasopharyngeal carcinoma
• T1-4N0-3M1,IVC(according to the 7th AJCC edition)
• Aged between 18 and 65 years
• KPS≥70
• The therapeutic effect evaluation is CR or PR accomplished three course of cisplatin and 5-Fu
• Voluntary to participate and sign informed consent document

Exclusion Criteria:

• The patients suffered from serious neurologic disease
• Clinically significant cardiac, heart function less than or equal to 3 level
• Clinically significant respiratory disease,lung function less than or equal to 3 level
• Blood routine examination: WBC<3×109/L, Hemoglobin<90g/L, platelet count<75×109/L
• Abnormal liver function: total bilirubin or ALT or AST>2×ULN
• Abnormal renal function:serum creatinine>1.5×ULN
• Pregnant or lactating women
• The therapeutic effect evaluation is SD or PD accomplished three course of cisplatin and 5-Fu