Efficacy Study of Articaine Lozenge to Enhance the Procedural Compliance of the Adults Undergoing Gastroduodenoscopy

Comparison of Novel Articaine Lozenge Versus Placebo for Upper Gastrointestinal Endoscopy in Adults. A Randomized Double-blinded Controlled Study

The purpose of this study is to examine in prospective, double-blinded randomised manner the ability of novel articaine-containing lozenge to enhance the procedure related compliance (compared to placebo) of the adult patients undergoing upper gastrointestinal endoscopy.

Inclusion Criteria:

• elective procedure
• weight over 40 kg
• American Society of Anesthesiology class I-III
• first upper GI endoscopy procedure
• finnish or/and swedish speaking

Exclusion Criteria:

• amide and/or esther local anaesthetic allergy
• paraben allergy
• Child-Pugh grade B/C liver failure
• renal insufficiency (calculated glomerular filtration rate under 60 ml/min/1.73 m2 according to Cockcroft-Gault scale )
• dementia
• those presenting with swallowing problem
• chronic pain condition
• chronic use of pain medication
• pregnancy
• lactation