Diagnostic Accuracy of Pleural Effusion Aspergillosis Biomarker Testing

Open Multicenter Diagnostic Study on the Accuracy of Biomarker Testing (Galactomannan (GM), (1-3)-β-D-glucan (BDG), Aspergillus-specific Polymerase Chain Reaction (PCR) Assay) in Pleural Effusion Samples of Immunocompromised Patients With Suspected Invasive Pulmonary Aspergillosis (IPA)

Diagnostic accuracy of biomarker testing (galactomannan (GM), (1

A multicentre, open, prospective diagnostic study on the diagnostic accuracy of biomarker testing (galactomannan (GM), (1

Inclusion Criteria:

• prolonged neutropenia > 10 d, patients
• after allogeneic stem cell transplantation or solid organ transplantation,
• Patients wth acute leukemia in induction treatment,
• patients witrh graft-versus-host-disease,
• patients under chronic immunusuppressive therapy such as ciclosporin,
• patients with HIV,
• patients with chronic steroid treatment

Exclusion Criteria:

• Age < 18 years
• missing informed consent
• contraindication for pleural centesis