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Diagnosing invasive pulmonary aspergillosis (IPA) remains a challenge in patients (pts) with hematological malignancies. The clinical significance of testing bronchoalveolar lavage (BAL) samples both with polymerase chain reaction (PCR) and Aspergillus galactomannan (GM) ELISA is unclear, and the BAL cutoff for GM has not been clearly defined yet. Using a validated nested PCR assay and a GM ELISA, we prospectively examine BAL samples from hematological patients at high risk of PA.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Hematological patients with proven or probable aspergillosis | |||
| Hematological patients with possible aspergillosis |
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| Measure | Description | Time Frame |
|---|---|---|
| Clinical significance of biomarker based diagnostic investigation in suspected invasive aspergillosis | up to 18 months |
| Measure | Description | Time Frame |
|---|---|---|
| Evaluation of diagnostic and therapeutic intervention concerning antifungal treatment with regard to outcome (overall survival, in months) of a fungal infection | up to 18 months |
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Inclusion Criteria:
- hematological patients with lung infiltrates at high risk for invasive aspergillosis
Exclusion Criteria:
- patients without informed consent
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hematological patients at high risk for invasive aspergillosis
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| Name | Affiliation | Role |
|---|---|---|
| Dieter Buchheidt, MD | Mannheim University Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Innsbruck University Hospital | Innsbruck | Austria | ||||
| Cologne University Hospital |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 10565898 | Background | Skladny H, Buchheidt D, Baust C, Krieg-Schneider F, Seifarth W, Leib-Mosch C, Hehlmann R. Specific detection of Aspergillus species in blood and bronchoalveolar lavage samples of immunocompromised patients by two-step PCR. J Clin Microbiol. 1999 Dec;37(12):3865-71. doi: 10.1128/JCM.37.12.3865-3871.1999. | |
| 11462176 | Background |
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| Cologne |
| Germany |
| Erlangen University Hospital | Erlangen | Germany |
| General Hospital Frankfurt (Oder) | Frankfurt (Oder) | Germany |
| Freiburg University Hospital | Freiburg im Breisgau | Germany |
| Halle University Hospital | Halle | Germany |
| Herne University Hospital | Herne | Germany |
| Mannheim University Hospital | Mannheim | 68167 | Germany |
| Würzburg University Hospital | Würzburg | Germany |
| Buchheidt D, Baust C, Skladny H, Ritter J, Suedhoff T, Baldus M, Seifarth W, Leib-Moesch C, Hehlmann R. Detection of Aspergillus species in blood and bronchoalveolar lavage samples from immunocompromised patients by means of 2-step polymerase chain reaction: clinical results. Clin Infect Dis. 2001 Aug 15;33(4):428-35. doi: 10.1086/321887. Epub 2001 Jul 6. |
| 12734210 | Background | Spiess B, Buchheidt D, Baust C, Skladny H, Seifarth W, Zeilfelder U, Leib-Mosch C, Morz H, Hehlmann R. Development of a LightCycler PCR assay for detection and quantification of Aspergillus fumigatus DNA in clinical samples from neutropenic patients. J Clin Microbiol. 2003 May;41(5):1811-8. doi: 10.1128/JCM.41.5.1811-1818.2003. |
| 20374275 | Background | Hummel M, Spiess B, Cornely OA, Dittmer M, Morz H, Buchheidt D. Aspergillus PCR testing: results from a prospective PCR study within the AmBiLoad trial. Eur J Haematol. 2010 Aug;85(2):164-9. doi: 10.1111/j.1600-0609.2010.01452.x. Epub 2010 Apr 1. |
| ID | Term |
|---|---|
| D001228 | Aspergillosis |
| D000095384 | Pathologic Complete Response |
| ID | Term |
|---|---|
| D009181 | Mycoses |
| D001423 | Bacterial Infections and Mycoses |
| D007239 | Infections |
| D018450 | Disease Progression |
| D020969 | Disease Attributes |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
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