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The purpose of this study was to compare the treatment effectiveness of steroid therapy for vestibular neuritis by using video head impulse test.
This study was a prospective, randomized controlled study. The enrolled vestibular neuritis patients were randomized to conservative treatment or steroid treatment when they are diagnosed with caloric test. After initial vestibular work-up including caloric, video head impulse tests, and a questinnaire (DHI), the patient was examined with the same tests again at 6 months later. The efficacy of steroid for the patients with vestibular neuritis would be determined by the comparison of the data of each group.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| : Ginkgo biloba & methylprednisolone | Active Comparator | Patients receive Ginkgo biloba & methylprednisolone per oral. |
|
| Ginkgo biloba | Placebo Comparator | Patients receive Ginkgo biloba per oral. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Ginkgo biloba & Methylprednisolone | Drug | Ginkgo biloba 160 mg/day (per oral, 80 mg twice a day) for 1 month. Methylprednisolone 48 mg/day(per oral, once a day for first 9 days. And then methylprednisolone tapering was started every 2 days. The entire duration of methylprednisolone treatment was 14 days. |
| Measure | Description | Time Frame |
|---|---|---|
| The improvement in vestibular function test (caloric & videop HIT) after treatment | The effectiveness of steroid therapy was determined by comparing the improvement of vestibular function (the degree of canal paresis by caloric test; gain and presence of refixation-saccade by video HIT test). | The first results were collected at initial diagnosis. And following results were collected 6 months after the first exam. |
| Measure | Description | Time Frame |
|---|---|---|
| The improvement in dizziness handicap inventory after treatment | The effectiveness of steroid therapy was determined by comparing improvement of subjective symptoms (symptom score by DHI) in each group. | The first results were collected at initial diagnosis. And following results were collected 6 months after the first exam. |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Hong Ju Park, Professor | Asan Medical Center | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Asan Medical Center | Seoul | Songpa-gu | 138-736 | South Korea |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 28391531 | Derived | Yoo MH, Yang CJ, Kim SA, Park MJ, Ahn JH, Chung JW, Park HJ. Efficacy of steroid therapy based on symptomatic and functional improvement in patients with vestibular neuritis: a prospective randomized controlled trial. Eur Arch Otorhinolaryngol. 2017 Jun;274(6):2443-2451. doi: 10.1007/s00405-017-4556-1. Epub 2017 Apr 8. |
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| ID | Term |
|---|---|
| D020338 | Vestibular Neuronitis |
| D014717 | Vertigo |
| ID | Term |
|---|---|
| D000160 | Vestibulocochlear Nerve Diseases |
| D012181 | Retrocochlear Diseases |
| D004427 | Ear Diseases |
| D010038 | Otorhinolaryngologic Diseases |
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| ID | Term |
|---|---|
| D000096983 | Ginkgo Extract |
| D008775 | Methylprednisolone |
| ID | Term |
|---|---|
| D010936 | Plant Extracts |
| D028321 | Plant Preparations |
| D001688 | Biological Products |
| D045424 | Complex Mixtures |
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|
|
| Ginkgo biloba | Drug | Ginkgo biloba 160 mg/day (per oral, 80 mg twice a day) for 1 month. |
|
|
| D003389 | Cranial Nerve Diseases |
| D009422 | Nervous System Diseases |
| D015837 | Vestibular Diseases |
| D007759 | Labyrinth Diseases |
| D009461 | Neurologic Manifestations |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D011239 |
| Prednisolone |
| D011246 | Pregnadienetriols |
| D011245 | Pregnadienes |
| D011278 | Pregnanes |
| D013256 | Steroids |
| D000072473 | Fused-Ring Compounds |
| D011083 | Polycyclic Compounds |