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| ID | Type | Description | Link |
|---|---|---|---|
| 2013-A01622-43 | Other Identifier | ANSM |
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This prospective study focuses on the interest of the echocardiography for cirrhotic patients, who present acute kidney injury corresponding to the criteria of hepatorenal syndrome. This echocardiography will be done before the volemic expansion and the final diagnostic of hepatorenal syndrome or prerenal azotemia. The primary endpoint is to describe the hemodynamic characteristics of this population at the time of acute kidney injury and their association with diagnostic of hepatorenal syndrome or prerenal azotemia. Patients with elevated filling pressure, predicting poor outcome of volemic expansion will be excluded of the study after the echocardiography and will not undergo volemic expansion but appropriate management.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| cirrhosis with portal hypertension,ascite and acute kidney | Other |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Echocardiography | Procedure |
|
| Measure | Description | Time Frame |
|---|---|---|
| Hemodynamic features assessed by echocardiography before the volemic expansion of cirrhotic patients with acute renal injury corresponding to the criteria of hepatorenal syndrome. | Systolic and diastolic function assessment, filling pressures, pulmonary arterial hypertension | At Day0 : at the time of diagnostic of acute kidney injury, before volemic expansion. |
| Measure | Description | Time Frame |
|---|---|---|
| Tolerance of volemic expansion, as recommended by international guidelines | Clinical tolerance of volemic expansion, acute pulmonary oedema | After 48 hours of volemic expansion |
| Response to vasoconstrictor treatment of hepatorenal syndrome, in case of diagnostic of hepatorenal syndrome |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Fanny LEBOSSE, Dr | Hospices Civils de Lyon | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Hospices Civils de Lyon - Hôpital de la Croix-Rousse | Lyon | 69004 | France |
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| ID | Term |
|---|---|
| D005355 | Fibrosis |
| D006530 | Hepatorenal Syndrome |
| D058186 | Acute Kidney Injury |
| ID | Term |
|---|---|
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D008107 | Liver Diseases |
| D004066 | Digestive System Diseases |
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Renal function recovery, renal replacement therapy, liver transplantation |
| 1 month after inclusion |
| Mortality | 1 month after inclusion |
| D007674 | Kidney Diseases |
| D014570 | Urologic Diseases |
| D052776 | Female Urogenital Diseases |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
| D052801 | Male Urogenital Diseases |
| D051437 | Renal Insufficiency |