Study of Methacholine Chloride Inhalation Challenge in Children With Bronchial Asthma

Study of Methacholine Chloride Inhalation Challenge in Children With Bronchial Asthma

The Purpose of this study is to evaluate the safety and efficacy of SK-1211 inhalation challenge in children with bronchial asthma.

Inclusion Criteria:

• Diagnosis of bronchial asthma
• FEV1/FVC must be 70% or more
• <10% decrease in FEV1 in response to inhalation of normal saline

Exclusion Criteria:

• Moderate or severe airflow limitation（FEV1<60% predicted）
• Heart attack or stroke in last 3 months
• Uncontrolled hypertension, systolic BP>200, or diastolic BP>100
• known aortic aneurysm