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| ID | Type | Description | Link |
|---|---|---|---|
| PH2014 | Other Grant/Funding Number | Uppsala University |
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| Name | Class |
|---|---|
| Uppsala University Hospital | OTHER |
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Obesity bariatric surgery patients usually lose more than 50% of their former obesity within a relatively short time (~ 2 years). There is still a lack of knowledge about underlying psychological and biological mechanisms of decline in body weight. The intention of this project is to investigate whether bariatric surgery is associated with patients' cognitive ability, lifestyle and/or gene expression and metabolomics.
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| Measure | Description | Time Frame |
|---|---|---|
| Changes in gene expression profile (a.o. FTO, BDNF) following a standardized meal (before vs. after surgery) | Gene expression profiling (whole genome analysis, with first interest in FTO and BDNF expression) to assess changes in gene expression before vs. after surgery, and to associate gene expression with weight loss after surgery | 1 year |
| Measure | Description | Time Frame |
|---|---|---|
| The effect of bariatric surgery on cognitive functioning (inhibitory control, selective attention) | No-Go go task (to assess inhibitory control) and Stroop tasks (to assess selective attention) will be measured to assess change in these cognitive functions before vs. after surgery, and to associate cognitive functioning with weight loss after surgery | Measures 1 y, 2 y, and 5 y after surgery. |
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Inclusion Criteria:
Exclusion Criteria:
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Obese patients with bariatric surgery
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Magnus Sundbom, MD | Contact | magnus.sundbom@akademiska.se | ||
| Didi Nordberg, MSc | Contact | didi.nordberg@gmail.com |
| Name | Affiliation | Role |
|---|---|---|
| Magnus Sundbom, MD | Academic Hospital Uppsala | Principal Investigator |
| Helgi Schiöth, Prof | Uppsala University | Study Director |
| Olga Titova, PhD |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Uppsala University Hospital | Recruiting | Uppsala | Sweden |
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| ID | Term |
|---|---|
| D009767 | Obesity, Morbid |
| D009765 | Obesity |
| D050177 | Overweight |
| ID | Term |
|---|---|
| D044343 | Overnutrition |
| D009748 | Nutrition Disorders |
| D009750 | Nutritional and Metabolic Diseases |
| D001835 | Body Weight |
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A fasted blood sample (50 mL) will be taken before and 2h after a standardized meal.
Through epigenetic study, we will analyze the changes in DNA methylation after surgery in genes related to metabolism (at the Science for Life Laboratory (SciLifeLab) with 450K Human Meth arrays).
In addition, blood samples from these obese patients analyzed (before and after surgery) after ingestion of a predetermined test meal (for example, high protein) to explore changes in metabolites profile. Metabolites in the samples will be quantified by the SciLifeLab.
| Uppsala University |
| Study Director |
| D012816 |
| Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |