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| ID | Type | Description | Link |
|---|---|---|---|
| EPN 2012/451 | Other Identifier | Ethical Board Uppsala |
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| Name | Class |
|---|---|
| Uppsala University Hospital | OTHER |
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After obesity surgery gastric bypass (GBP) patients usually lose more than 50% of its former preponderance in relative short time (~ 2 years). But knowledge of the underlying biological mechanisms of decline in body weight is still inadequate.
This project intends to examine patients' background activity in the brain (i.e. "the resting state activity") and brain volume using MRI both before and one year after surgery.
We will also investigate whether hormonal changes in response to food intake after obesity surgery is associated with patients' impulsive control when exposed to pictures of food in the MRI.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Bariatric surgery | Experimental | patients participating in the intervention group , i.e. assessing effects of bariatric surgery on: Brain activity in resting state Memory performance |
|
| Control | Active Comparator | Patients in the control group will not undergo surgery during study. These patients will be examined twice:
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Bariatric surgery | Procedure | Gastric bypass surgery |
| |
| Measure | Description | Time Frame |
|---|---|---|
| Change in background activity in the brain (resting state activity) after bariatric surgery | Brain's basic activity and structure will be measured on 3 occasions: 4 weeks before bariatric surgery, 4 weeks after surgery and 1 year after surgery, using fMRI. | 1 year |
| Measure | Description | Time Frame |
|---|---|---|
| Change in response inhibition after bariatric surgery | Inhibitory control to food cues will be measured on 3 occasions: 4 weeks before bariatric surgery, 4 weeks after surgery and 1 year after surgery, using a NoGo-Go task. | 1 year |
| Measure | Description | Time Frame |
|---|---|---|
| Change in memory-function after bariatric surgery ("concentration") | Memory performance will be measured on 3 occasions: 4 weeks before bariatric surgery, 4 weeks after surgery and 1 year after surgery - using a a 2D-object location task ("memory game") | 1 year |
Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Magnus Sundbom, MD | Academic Hospital Uppsala | Study Director |
| Christian Benedict, PhD | Uppsala University | Study Director |
| Pleunie Hogenkamp, PhD | Uppsala University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Academic Hospital | Uppsala | Sweden |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 42210737 | Derived | Andreoli MF, De Francesco PN, Zhou W, Titova OE, Alsehli A, Fredriksson R, Sundbom M, Perello M, Schioth HB. Associations of PYY, GLP-1 and LEAP2 with changes in feeding-related cognition, body weight and glucose homeostasis after bariatric surgery in non-diabetic women. J Neuroendocrinol. 2026 Jun;38(6):e70207. doi: 10.1111/jne.70207. |
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| ID | Term |
|---|---|
| D009765 | Obesity |
| ID | Term |
|---|---|
| D050177 | Overweight |
| D044343 | Overnutrition |
| D009748 | Nutrition Disorders |
| D009750 | Nutritional and Metabolic Diseases |
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| ID | Term |
|---|---|
| D050110 | Bariatric Surgery |
| ID | Term |
|---|---|
| D049088 | Bariatrics |
| D000073319 | Obesity Management |
| D013812 | Therapeutics |
| D013514 | Surgical Procedures, Operative |
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| Brain activity in resting state |
| Behavioral |
Measure of activity in brain networks during resting state |
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| Memory performance | Behavioral | Assess concentration in 2D-location task (i.e. "memory game") |
|
| D001835 |
| Body Weight |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |