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Non-alcoholic fatty liver disease (NAFLD) is characterized by an accumulation of fat in the liver, which is one of the most common forms of chronic liver disease in developed countries. In western countries, the prevalence of NAFLD in the general population is estimated to be 20-30%; in obese populations, this increases to 57.5-74%. But, it hasn't been clearly elucidated yet regarding the underlying disease pathophysiology and treatmet strategy.
Recently, members of the C1q/tumor necrosis factor-related protein (CTRP) family have been reported to share structural homology with adiponectin. To date, 15 CTRP family members have been found that might play major roles in glucose metabolism and inflammation.
The investigators tried to clarify the relationship between CTRP family and NAFLD in Korean men and women.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Patients with NAFLD |
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| Measure | Description | Time Frame |
|---|---|---|
| serum concentration of CTRP-1, 3, or 9 in the subjects with/without NAFLD | at enrollment |
| Measure | Description | Time Frame |
|---|---|---|
| The relationships of serum CTRPs/adiponectin levels with cardiometabolic risk profiles | at enrollment |
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Inclusion Criteria:
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The subjects who visited for a routine health check-up at the Health Promotion Center of Korea University Guro Hospital were enrolled using predefined inclusion and exclusion criteria.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Ho Cheol Hong, M.D. | Contact | 822-2626-3044 | naeyo21@naver.com | |
| Kyung Mook Choi, M.D. | Contact | 822-2626-3043 | medica7@gmail.com |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Korea Univ. Guro Hospital | Recruiting | Seoul | South Korea |
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| ID | Term |
|---|---|
| D065626 | Non-alcoholic Fatty Liver Disease |
| ID | Term |
|---|---|
| D005234 | Fatty Liver |
| D008107 | Liver Diseases |
| D004066 | Digestive System Diseases |
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