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Nonalcoholic fatty liver disease (NAFLD) is the most common type of liver disease in the United States. The incidence of NAFLD is very similar to that of obesity, type 2 diabetes, and the metabolic syndrome. The investigators hypothesize that there may be a relationship between over-nutrition, decreased physical activity and the development of fatty liver. The purpose of this study is to identify the types of fats and proteins, and the quantity of each, that are associated with increased severity of NAFLD.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Obese, bariatric surgery, liver biopsy | Obese subjects approved and scheduled for bariatric surgery at Vanderbilt University Medical Center | ||
| Normal BMI, abdominal surgery, liver biopsy | Normal weight subjects having elective abdominal surgery at Vanderbilt University Medical Center. | ||
| Liver transplantation donors and recipients | All livers made available for implantation or explantation will be eligible. |
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| Measure | Description | Time Frame |
|---|---|---|
| To identify and relatively quantify, using high performance liquid chromatography electrospray ionization mass spectrometry, select lipids and proteins present in human liver biopsies. | 2 years | |
| To spatially profile, using matrix assisted laser desorption ionization time of flight mass spectrometry, select lipids and proteins present in human liver biopsies. | 2 years |
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Inclusion Criteria:
Exclusion Criteria:
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Subjects having bariatric surgery or elective abdominal surgery at Vanderbilt University Medical Center
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| Name | Affiliation | Role |
|---|---|---|
| Charles R Flynn, PhD | Vanderbilt University Medical Center | Principal Investigator |
| Najji Abumrad, MD | Vanderbilt University Medical Center | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Vanderbilt University Medical Center | Nashville | Tennessee | 37232 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 26599819 | Derived | Garcia AE, Kasim N, Tamboli RA, Gonzalez RS, Antoun J, Eckert EA, Marks-Shulman PA, Dunn J, Wattacheril J, Wallen T, Abumrad NN, Flynn CR. Lipoprotein Profiles in Class III Obese Caucasian and African American Women with Nonalcoholic Fatty Liver Disease. PLoS One. 2015 Nov 23;10(11):e0142676. doi: 10.1371/journal.pone.0142676. eCollection 2015. |
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| ID | Term |
|---|---|
| D065626 | Non-alcoholic Fatty Liver Disease |
| D009765 | Obesity |
| ID | Term |
|---|---|
| D005234 | Fatty Liver |
| D008107 | Liver Diseases |
| D004066 | Digestive System Diseases |
| D050177 | Overweight |
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liver biopsy, blood, plasma
| D044343 |
| Overnutrition |
| D009748 | Nutrition Disorders |
| D009750 | Nutritional and Metabolic Diseases |
| D001835 | Body Weight |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |