Effects of Long Term Calorie Restriction on Sphingomyelin and Amino Acids

Three-year Mild Calorie Restriction Partially Protects Against Age-related Increase in Sphingomyelin and Reduces Obesity-associated Amino Acids

The effect of weight loss with long-term low calorie diet (LCD) on plasma metabolites is unknown. The aim was to examine whether a LCD-induced weight reduction results in changes in the extended plasma metabolites.

Overweight/obese subjects (25≤ BMI <33 kg/m2) aged 40 to 59 years consumed a LCD (an approximate 100 kcal/day calorie deficit) or a weight-maintenance diet (control) in a randomized, controlled design with 3-year intervention period.

Inclusion Criteria:

• 25 <= BMI < 33 kg/m2

Exclusion Criteria:

• type 2 diabetes
• cardiovascular disease
• psychiatric problems
• any medication use